Neural and behavioral correlates of extended training during sleep deprivation in humans: evidence for local, task-specific effects

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Giulio BernardiGiulio Tononi

Abstract

Recent work has demonstrated that behavioral manipulations targeting specific cortical areas during prolonged wakefulness lead to a region-specific homeostatic increase in theta activity (5-9 Hz), suggesting that theta waves could represent transient neuronal OFF periods (local sleep). In awake rats, the occurrence of an OFF period in a brain area relevant for behavior results in performance errors. Here we investigated the potential relationship between local sleep events and negative behavioral outcomes in humans. Volunteers participated in two prolonged wakefulness experiments (24 h), each including 12 h of practice with either a driving simulation (DS) game or a battery of tasks based on executive functions (EFs). Multiple high-density EEG recordings were obtained during each experiment, both in quiet rest conditions and during execution of two behavioral tests, a response inhibition test and a motor test, aimed at assessing changes in impulse control and visuomotor performance, respectively. In addition, fMRI examinations obtained at 12 h intervals were used to investigate changes in inter-regional connectivity. The EF experiment was associated with a reduced efficiency in impulse control, whereas DS led to a relative impa...Continue Reading

Citations

Jan 26, 2016·Current Biology : CB·Chadd M FunkGiulio Tononi
Dec 5, 2015·Frontiers in Neurology·Christel Gudberg, Heidi Johansen-Berg
Oct 19, 2016·Sleep Medicine Reviews·Brice FarautDamien Leger
Apr 24, 2017·Brain Topography·Serena ScarpelliLuigi De Gennaro
Apr 4, 2019·Journal of Neurophysiology·Giulio BernardiFrancesca Siclari
Oct 30, 2018·European Journal of Physical and Rehabilitation Medicine·Caterina TramontiCarmelo Chisari
Jun 1, 2017·Journal of Cognitive Neuroscience·Lampros PerogamvrosGiulio Tononi
Apr 7, 2020·Annual Review of Neuroscience·David A McCormickBiyu J He
Oct 15, 2019·Frontiers in Neuroscience·Hugo F Posada-QuinteroKi H Chon
Apr 19, 2018·Frontiers in Human Neuroscience·Angelica QuerciaMichele Ferrara
Nov 5, 2019·Frontiers in Neuroscience·Sasha D'AmbrosioSergio Garbarino
May 30, 2019·Sleep & Breathing = Schlaf & Atmung·P K HitchcottA Gemignani
Jun 3, 2017·Current Opinion in Neurobiology·Francesca Siclari, Giulio Tononi
Apr 8, 2021·BMC Biology·Linus MilinskiVladyslav V Vyazovskiy
Jul 1, 2021·Nature Communications·Thomas AndrillonNaotsugu Tsuchiya
Jul 24, 2021·Cerebral Cortex Communications·Christian WienkeStefan Dürschmid
Aug 3, 2021·Frontiers in Neuroscience·Serena RicciM Felice Ghilardi
Dec 19, 2020·Biochemical Pharmacology·Whitney Stee, Philippe Peigneux
Oct 8, 2021·Journal of Cognitive Neuroscience·Giulia AvvenutiGiulio Bernardi

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