PMID: 860697May 26, 1977Paper

Neural and psychologic mechanisms and the problem of sudden cardiac death

The American Journal of Cardiology
B LownS H Rabinowitz


Brain stimulation can provoke a variety of arrhythmias and lower the ventricular vulnerable threshold. In the animal with acute myocardial ischemia such stimuli suffice to provoke ventricular fibrillation. Vagal neural traffic or adrenal catecholamines are not the conduits for this brain-heart linkage. Accompanying increases in heart rate or blood pressure are not prerequisites for the changes in cardiac excitability. Increased sympathetic activity, whether induced by neural or neurohumoral action, predisposes the heart to ventricular fibrillation. Protection can be achieved with surgical and pharmacologic denervation or reflex reduction in sympathetic tone. With acute myocardial ischemia, augmented sympathetic activity accounts for the early surge of ectopic activity frequently precipitating ventricular fibrillation. Asymmetries in sympathetic neural discharge may also contribute to the genesis of serious arrhythmias. The vagus nerve, through its muscarinic action, exerts an indirect effect on cardiac vulnerability, the consequence of annulment of concomitant adrenergic influence, rather than of any direct cholinergic action on the ventricles. There exist anatomic, physiologic as well as molecular bases for such interactions. ...Continue Reading

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Jun 1, 1975·American Heart Journal·T WeissK Engelman
May 20, 1976·The New England Journal of Medicine·B Lown, R L Verrier
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Feb 10, 1977·The New England Journal of Medicine·B LownC E Gaughan
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Jan 1, 1969·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K Löffelholz, E Muscholl
Mar 1, 1971·Circulation Research·P J LaRaia, E H Sonnenblick
Nov 1, 1971·Circulation Research·M N Levy
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Nov 1, 1973·The American Journal of Psychiatry·R H RaheR J Arthur
Feb 1, 1974·Archives of Internal Medicine·R H RaheP Siltanen
Apr 1, 1974·The American Journal of Physiology·R VerrierP Axelrod
Jun 1, 1971·The American Journal of Cardiology·M J BurgessL S Green

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