Neural architecture: from cells to circuits

Journal of Neurophysiology
Sarah E V Richards, Stephen D Van Hooser

Abstract

Circuit operations are determined jointly by the properties of the circuit elements and the properties of the connections among these elements. In the nervous system, neurons exhibit diverse morphologies and branching patterns, allowing rich compartmentalization within individual cells and complex synaptic interactions among groups of cells. In this review, we summarize work detailing how neuronal morphology impacts neural circuit function. In particular, we consider example neurons in the retina, cerebral cortex, and the stomatogastric ganglion of crustaceans. We also explore molecular coregulators of morphology and circuit function to begin bridging the gap between molecular and systems approaches. By identifying motifs in different systems, we move closer to understanding the structure-function relationships that are present in neural circuits.

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Citations

Aug 12, 2021·FASEB BioAdvances·Andrea SchnatzEva-Maria Krämer-Albers
Nov 17, 2021·Neural Regeneration Research·Rafhanah Banu Bte Abdul RazarJohn Jia En Chua

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Methods Mentioned

BETA
imaging techniques
GTPases
GTPase

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