PMID: 8592170Jan 1, 1995Paper

Neural cell adhesion molecule expression in human pituitary adenomas

Journal of Neuro-oncology
B K Kleinschmidt-DeMastersC A Kruse

Abstract

Neural cell adhesion molecule (NCAM) is a cell surface glycoprotein whose expression may be important in metastatic or local growth of neoplasms. Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin's and/or formalin-fixed, paraffin-embedded archival tissue using a sensitive alkaline phosphatase-antialkaline phosphatase method of immunostaining with the monoclonal antibody, NKH-1. The 20 pituitary adenoma patients consisted of 13 males and 7 females, ages 19-78 years, with null cell macroadenomas (3), plurihormonal macroadenomas (4), weak gonadotropic macroadenomas (5), growth hormone-prolactin adenomas (2), and prolactinomas (6). Eight of the adenomas were clinically invasive. The snap-frozen material from 14 pituitary tumors showed immunostaining for NCAM in either a cytoplasmic, peripheral membranous, or mixed pattern; 2 of 3 prolactinomas showed patchy immunostaining. The Bouin's and/or formalin-fixed pituitary adenoma specimens from 6 clinically invasive cases showed less distinct NCAM localization but 4 out of 6 showed diffusely positive NCAM immunostaining, with greatest intensity appreciated on the Bouin's-fixed tissue. There was no correlation between NCAM staining pattern and invasive c...Continue Reading

References

Apr 1, 1992·British Journal of Cancer·K RygaardM Spang-Thomsen
May 1, 1992·Journal of Neurosurgery·W T CouldwellM C Kuppner
Jul 1, 1991·Journal of Clinical Pathology·E PhimisterK Patel
Apr 1, 1990·Biochemical Society Transactions·K PatelJ T Kemshead
Jun 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O K LangleyM Gratzl
Jan 1, 1986·Annual Review of Physiology·G M Edelman
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Hoffman, G M Edelman
Feb 4, 1983·Science·G M Edelman
Jan 1, 1993·Human Pathology·M Miettinen, W Cupo

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Citations

May 15, 2003·Journal of Neurosurgery·Jacqueline TrouillasDominique Figarella-Branger
Dec 22, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G A MendesJ F S Pereira-Lima
Sep 13, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·E R M SalehM M Marques
Oct 3, 1999·Annals of Clinical Biochemistry·I De JongJ M Burrin

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