Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer

Cancer Research
Judy YanDamu Tang

Abstract

Prostate cancer metastasis is the main cause of disease-related mortality. Elucidating the mechanisms underlying prostate cancer metastasis is critical for effective therapeutic intervention. In this study, we performed gene-expression profiling of prostate cancer stem-like cells (PCSC) derived from DU145 human prostate cancer cells to identify factors involved in metastatic progression. Our studies revealed contactin 1 (CNTN1), a neural cell adhesion protein, to be a prostate cancer-promoting factor. CNTN1 knockdown reduced PCSC-mediated tumor initiation, whereas CNTN1 overexpression enhanced prostate cancer cell invasion in vitro and promoted xenograft tumor formation and lung metastasis in vivo. In addition, CNTN1 overexpression in DU145 cells and corresponding xenograft tumors resulted in elevated AKT activation and reduced E-cadherin (CDH1) expression. CNTN1 expression was not readily detected in normal prostate glands, but was clearly evident on prostate cancer cells in primary tumors and lymph node and bone metastases. Tumors from 637 patients expressing CNTN1 were associated with prostate cancer progression and worse biochemical recurrence-free survival following radical prostatectomy (P < 0.05). Collectively, our findi...Continue Reading

References

Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Dec 26, 2002·Biology of the Cell·Julien FalkCatherine Faivre-Sarrailh
Mar 15, 2006·Cancer Cell·Jen-Liang SuMin-Liang Kuo
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karsten GravdalLars A Akslen
Jan 18, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert W VeltriAlan W Partin
Sep 12, 2008·Nature Reviews. Cancer·Jane E Visvader, Geoffrey J Lindeman
Oct 14, 2008·Expert Opinion on Biological Therapy·Nancy GavertAvri Ben-Ze'ev
Oct 24, 2008·Nature·Kevin G LeongWei-Qiang Gao
Nov 7, 2008·Journal of Cellular Physiology·Shijie ShengArthur B Pardee
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jul 31, 2010·Science·Andrew S GoldsteinOwen N Witte
Feb 7, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Josephine HaiMing-Sound Tsao
Mar 1, 2012·Developmental Biology·Antonella BizzocaGianfranco Gennarini
May 11, 2012·Experimental & Molecular Medicine·Chun Hua Wei, Seong Eon Ryu
Aug 8, 2012·The Journal of Cell Biology·Irène Baccelli, Andreas Trumpp
Feb 12, 2013·Evolutionary Applications·Mel Greaves
Jul 13, 2013·EMBO Reports·Felipe De Sousa E MeloJan Paul Medema
Oct 19, 2013·Cancer Cell·Sakari Vanharanta, Joan Massagué
Dec 11, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Jan 28, 2014·Biochemistry. Biokhimii︠a︡·T S GerashchenkoN V Cherdyntseva
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray

❮ Previous
Next ❯

Citations

Sep 27, 2016·Expert Review of Anticancer Therapy·Fable Zustovich, Davide Pastorelli
Apr 8, 2017·International Journal of Molecular Sciences·Xiaozeng LinDamu Tang
Jan 11, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Norelia TorrealbaMar Royuela
Jun 22, 2016·Current Opinion in Supportive and Palliative Care·Giorgio GandagliaAlberto Briganti
Feb 12, 2017·Oncotarget·Nicholas WongDamu Tang
Nov 21, 2017·Oncotarget·Kiera Rycaj, Dean G Tang
May 16, 2018·Annals of Clinical and Translational Neurology·Ana M SilesLuis Querol
Jun 18, 2019·Therapeutic Advances in Medical Oncology·Yanzhi JiangDamu Tang
Oct 27, 2020·Cancer Biomarkers : Section a of Disease Markers·Guangyao LiJianyu Zhu
Nov 17, 2020·Frontiers in Oncology·Yumei LiangHaining Zhang
Apr 4, 2021·Biomolecules·Yan GuDamu Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.