Jan 29, 2020

Neural Circuit Dynamics for Sensory Detection

bioRxiv
Sruti MallikShiNung Ching

Abstract

We consider the question of how sensory networks enable the detection of sensory stimuli in a combinatorial coding space. We are specifically interested in the olfactory system, wherein recent experimental studies have reported the existence of rich, enigmatic response patterns associated with stimulus onset and offset. This study aims to identify the functional relevance of such response patterns, i.e., what benefits does such neural activity provide in the context of detecting stimuli in a natural environment. We study this problem through the lens of normative, optimization-based modeling. Here, we define the notion of a low dimensional latent representation of stimulus identity, which is generated through action of the sensory network. The objective of our optimization framework is to ensure high fidelity tracking of a nominal representation in this latent space in an energy efficient manner. It turns out that the optimal motifs emerging from this framework possess morphological similarity with prototypical onset and offset responses observed in vivo. Furthermore, this objective can be exactly achieved by a network with reciprocal excitatory-inhibitory competitive dynamics, similar to interactions between principal neurons ...Continue Reading

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Mentioned in this Paper

Morphological
In Vivo
Environment
Question (Inquiry)
Sensory Symptoms
Research Study
Olfactory System
Insecta
Problem
Patterns

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