Neural circuit formation in the cerebellum is controlled by cell adhesion molecules of the Contactin family.

Cell Adhesion & Migration
Esther T Stoeckli

Abstract

Cell adhesion molecules of the immunoglobulin superfamily (IgSF CAMs) have been implicated in neural circuit formation in both the peripheral and the central nervous system. Several recent studies highlight a role of the Contactin group of IgSF CAMs in cerebellar development, in particular in the development of granule cells. Granule cells are the most numerous type of neurons in the nervous system and by forming a secondary proliferative zone in the cerebellum they provide an exception to the rule that neuronal precursors proliferate in the ventricular zone. Granule cells express Contactin-2, Contactin-1, and Contactin-6 in a sequential manner. Contactins are required for axon guidance, fasciculation, and synaptogenesis, and thus affect multiple steps in neural circuit formation in the developing cerebellum.

References

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Citations

Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masahito Yamagata, Joshua R Sanes
Oct 12, 2012·Neurochemical Research·Hansjürgen VolkmerFritz G Rathjen
Jun 20, 2012·The European Journal of Neuroscience·Esther T Stoeckli
Mar 1, 2012·Developmental Biology·Antonella BizzocaGianfranco Gennarini
Sep 7, 2016·Molecular and Cellular Neurosciences·Jeannine A Frei, Esther T Stoeckli
Sep 20, 2016·ELife·Kerry M GoodmanLawrence Shapiro
Jun 24, 2017·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Miki TakeuchiMasahiko Hibi
Aug 6, 2019·Frontiers in Cell and Developmental Biology·Sabrina PicocciGianfranco Gennarini
Jun 3, 2018·Alzheimer's Research & Therapy·Madhurima ChatterjeeCharlotte E Teunissen
Dec 12, 2018·Neural Regeneration Research·Madhurima ChatterjeeCharlotte E Teunissen
Dec 27, 2016·Frontiers in Molecular Neuroscience·Amila ZukoJ P H Burbach

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