Neural circuit remodeling and structural plasticity in the cortex during chronic pain

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Woojin Kim, Sun Kwang Kim

Abstract

Damage in the periphery or spinal cord induces maladaptive plastic changes along the somatosensory nervous system from the periphery to the cortex, often leading to chronic pain. Although the role of neural circuit remodeling and structural synaptic plasticity in the 'pain matrix' cortices in chronic pain has been thought as a secondary epiphenomenon to altered nociceptive signaling in the spinal cord, progress in whole brain imaging studies on human patients and animal models has suggested a possibility that plastic changes in cortical neural circuits may actively contribute to chronic pain symptoms. Furthermore, recent development in two-photon microscopy and fluorescence labeling techniques have enabled us to longitudinally trace the structural and functional changes in local circuits, single neurons and even individual synapses in the brain of living animals. These technical advances has started to reveal that cortical structural remodeling following tissue or nerve damage could rapidly occur within days, which are temporally correlated with functional plasticity of cortical circuits as well as the development and maintenance of chronic pain behavior, thereby modifying the previous concept that it takes much longer periods ...Continue Reading

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Citations

Aug 12, 2016·Frontiers in Human Neuroscience·Antonino NaroAngelo Quartarone
Oct 26, 2016·Neuroscience Letters·Jeongsoo HanBae Hwan Lee
Jul 3, 2019·Journal of Cell Science·Dina S Coelho, Eduardo Moreno

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Methods Mentioned

BETA
amputation
confocal microscopy

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