DOI: 10.1101/480830Nov 29, 2018Paper

Neural circuit robustness to acute, global physiological perturbations

BioRxiv : the Preprint Server for Biology
Jacob RatliffTimothy O'Leary


Neural function depends on underlying physiological processes that are highly sensitive to physical variables such as temperature. However, some robustness to perturbations in these variables manifests at the circuit level, suggesting that circuit properties are organized to tolerate consistent changes in underlying parameters. We show that a crustacean pacemaker circuit is robust to two global perturbations - temperature and pH - that differentially alter circuit properties. Consistent with high variability in underlying circuit parameters, we find that the critical temperatures and pH values where circuit activity breaks down vary widely across animals. Despite variability in critical points the network state transitions at these critical points are consistent, implying that qualitative circuit dynamics are preserved across animals, in spite of high quantitative parameter variability. Surprisingly, robustness perturbations in pH only moderately affect temperature robustness. Thus, robustness to a global perturbation does not necessarily imply sensitivity to other global perturbations.

Related Concepts

Subphylum Crustacea
Physiological Processes
Electronic Pacemaker

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

BRAIN Initiative Cell Census Network (BICCN)

The BRAIN Initiative Cell Census Network aims to identify and provide experimental access to the different brain cell types to determine their roles in health and disease. Discover the latest research from researchers in the BRAIN Initiative Cell Census Network here.

Related Papers

Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
Eve MarderTilman J Kispersky
Evolutionary Bioinformatics Online
Bor-Sen ChenWen-Hsiung Li
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Charlotte Haug
© 2021 Meta ULC. All rights reserved