Neural circuits for long-term water-reward memory processing in thirsty Drosophila

Nature Communications
Wei-Huan ShyuChia-Lin Wu

Abstract

The intake of water is important for the survival of all animals and drinking water can be used as a reward in thirsty animals. Here we found that thirsty Drosophila melanogaster can associate drinking water with an odour to form a protein-synthesis-dependent water-reward long-term memory (LTM). Furthermore, we found that the reinforcement of LTM requires water-responsive dopaminergic neurons projecting to the restricted region of mushroom body (MB) β' lobe, which are different from the neurons required for the reinforcement of learning and short-term memory (STM). Synaptic output from α'β' neurons is required for consolidation, whereas the output from γ and αβ neurons is required for the retrieval of LTM. Finally, two types of MB efferent neurons retrieve LTM from γ and αβ neurons by releasing glutamate and acetylcholine, respectively. Our results therefore cast light on the cellular and molecular mechanisms responsible for processing water-reward LTM in Drosophila.

References

Sep 16, 1966·Science·J L McGaugh
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B L TempelW G Quinn
Oct 7, 1994·Cell·T TullyM Del Vecchio
Mar 14, 1997·Science·W SchultzP R Montague
Apr 3, 2003·Nature Reviews. Neuroscience·Martin Heisenberg
Feb 26, 2004·Nature Genetics·Stephen T ThibaultJonathan Margolis
May 15, 2004·Science·Guillaume IsabelThomas Preat
Jul 19, 2005·Annual Review of Neuroscience·Ronald L Davis
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elisabeth FolkersWilliam G Quinn
Apr 25, 2007·Nature Reviews. Neuroscience·Alex C Keene, Scott Waddell
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael J Krashes, Scott Waddell
Apr 7, 2010·Nature·Peter CameronKristin Scott
Oct 4, 2011·Current Biology : CB·Séverine TrannoyThomas Preat
Jul 19, 2012·PLoS Genetics·Yoshinori AsoHiromu Tanimoto
Oct 23, 2012·Current Opinion in Neurobiology·Josh Dubnau, Ann-Shyn Chiang
Oct 30, 2012·Nature·Christopher J BurkeScott Waddell
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tsung-Pin PaiAnn-Shyn Chiang
Jun 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Isaac Cervantes-SandovalRonald L Davis
Jul 23, 2013·Nature·Tsai-Wen ChenDouglas S Kim
Feb 25, 2014·Nature Neuroscience·Andrew C LinGero Miesenböck
Jul 22, 2014·Current Biology : CB·Dana Shani GaliliHiromu Tanimoto
Sep 30, 2014·Nature Neuroscience·Suewei LinScott Waddell
Dec 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nobuhiro YamagataHiromu Tanimoto
Mar 3, 2015·Current Biology : CB·Wolf HuetterothScott Waddell
Mar 18, 2015·PloS One·Chia-Lin WuSheng-Rong Yeh
Jul 17, 2015·Nature Communications·Hsiang-Wen ShihAnn-Shyn Chiang
Aug 25, 2015·Current Biology : CB·Laurence P C LewisIlona C Grunwald Kadow
Nov 18, 2015·ELife·Toshiharu IchinoseHiromu Tanimoto

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Citations

Jan 8, 2020·Journal of Neurogenetics·Nadine Ehmann, Dennis Pauls
Mar 7, 2020·Communications Biology·Daniel Ari FriedmanDeborah M Gordon
May 4, 2018·Frontiers in Physiology·Eve G Lowenstein, Norma A Velazquez-Ulloa
Oct 30, 2019·Nature Neuroscience·Bhagyashree SenapatiSuewei Lin
Jan 31, 2021·Cell and Tissue Research·K P SijuIlona C Grunwald Kadow
Nov 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ted M HsuMitchell F Roitman
Dec 4, 2021·Frontiers in Cell and Developmental Biology·Wang-Pao LeeChia-Lin Wu

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Methods Mentioned

BETA
GTPase

Software Mentioned

GraphPad
Amira
Prism
ImageJ
ZEN

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