Neural coding: A single neuron's perspective

Neuroscience and Biobehavioral Reviews
Alireza AzarfarTansu Celikel

Abstract

What any sensory neuron knows about the world is one of the cardinal questions in Neuroscience. Information from the sensory periphery travels across synaptically coupled neurons as each neuron encodes information by varying the rate and timing of its action potentials (spikes). Spatiotemporally correlated changes in this spiking regimen across neuronal populations are the neural basis of sensory representations. In the somatosensory cortex, however, spiking of individual (or pairs of) cortical neurons is only minimally informative about the world. Recent studies showed that one solution neurons implement to counteract this information loss is adapting their rate of information transfer to the ongoing synaptic activity by changing the membrane potential at which spike is generated. Here we first introduce the principles of information flow from the sensory periphery to the primary sensory cortex in a model sensory (whisker) system, and subsequently discuss how the adaptive spike threshold gates the intracellular information transfer from the somatic post-synaptic potential to action potentials, controlling the information content of communication across somatosensory cortical neurons.

Citations

Feb 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Perry Zurn, Danielle S Bassett
Jun 2, 2020·Frontiers in Computational Neuroscience·Sterling Street
Dec 7, 2018·GigaScience·Angelica da Silva LantyerTansu Celikel
Aug 23, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Samantha Hughes, Tansu Celikel
Dec 3, 2020·ELife·Sweta AgrawalJohn C Tuthill
Mar 23, 2021·Frontiers in Neuroscience·Wenzhe GuoKhaled Nabil Salama
Mar 23, 2021·Frontiers in Neuroscience·Beck StrohmerLeon Bonde Larsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Related Papers

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Stefano PanzeriRasmus S Petersen
Current Opinion in Neurobiology
Robert Gütig
Current Opinion in Neurobiology
Rasmus S PetersenMathew E Diamond
© 2022 Meta ULC. All rights reserved