Neural coding of natural stimuli: information at sub-millisecond resolution

PLoS Computational Biology
Ilya NemenmanRob de Ruyter van Steveninck


Sensory information about the outside world is encoded by neurons in sequences of discrete, identical pulses termed action potentials or spikes. There is persistent controversy about the extent to which the precise timing of these spikes is relevant to the function of the brain. We revisit this issue, using the motion-sensitive neurons of the fly visual system as a test case. Our experimental methods allow us to deliver more nearly natural visual stimuli, comparable to those which flies encounter in free, acrobatic flight. New mathematical methods allow us to draw more reliable conclusions about the information content of neural responses even when the set of possible responses is very large. We find that significant amounts of visual information are represented by details of the spike train at millisecond and sub-millisecond precision, even though the sensory input has a correlation time of approximately 55 ms; different patterns of spike timing represent distinct motion trajectories, and the absolute timing of spikes points to particular features of these trajectories with high precision. Finally, the efficiency of our entropy estimator makes it possible to uncover features of neural coding relevant for natural visual stimuli...Continue Reading


Aug 1, 1976·Quarterly Reviews of Biophysics·W Reichardt, T Poggio
Jun 28, 1991·Science·William BialekD Warland
Sep 1, 1986·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·W Heiligenberg, G Rose
Oct 30, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·P V Byrne, I V Chapman
Jul 1, 1966·Psychological Bulletin·R H Price
Jan 1, 1993·Annual Review of Neuroscience·C E Carr
Jun 1, 1995·Journal of Computational Neuroscience·F Theunissen, J P Miller
Aug 1, 1996·Journal of Neurophysiology·Jonathan D Victor, K P Purpura
Sep 1, 1996·International Journal of Neural Systems·Rob de Ruyter van Steveninck, S B Laughlin
Mar 21, 1997·Science·Rob de Ruyter van SteveninckWilliam Bialek
May 1, 1997·Journal of Neurophysiology·D S ReichE Kaplan
Dec 1, 1995·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D H Wolpert, D R Wolf
Aug 10, 2000·Neural Computation·N BrennerRob de Ruyter van Steveninck
Sep 21, 2001·Network : Computation in Neural Systems·G D LewenRob de Ruyter van Steveninck
Dec 4, 2001·Journal of Neurophysiology·R C LiuK D Miller
Feb 28, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ilya Nemenman, William Bialek
Jan 7, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jonathan D Victor
May 17, 2003·Biological cybernetics·Martin P NawrotStefan Rotter
Jul 13, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ilya NemenmanRob de Ruyter van Steveninck
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J H van HaterenM Egelhaaf
May 20, 2005·Neural Computation·Matthew B KennelE J Chichilnisky


Jun 13, 2014·Neural Computation·Nicholas Watters, George N Reeke
Jun 13, 2014·Current Opinion in Biotechnology·Andre Levchenko, Ilya Nemenman
Oct 30, 2010·IET Systems Biology·A MuglerC H Wiggins
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Amy Wells QuinkertDonald W Pfaff
May 17, 2011·PLoS Computational Biology·Zane N AldworthJohn P Miller
Sep 17, 2011·Science·Raymond CheongAndre Levchenko
Nov 16, 2010·IET Systems Biology·A A MargolinIlya Nemenman
Nov 28, 2012·Journal of Physiology, Paris·Anne-Kathrin WarzechaJan Grewe
Jul 17, 2012·Current Opinion in Neurobiology·Adrienne FairhallAndrea Barreiro
Aug 9, 2011·The European Journal of Neuroscience·Diana RienRafael Kurtz
Sep 18, 2015·Frontiers in Computational Neuroscience·Sarah MarzenJames P Crutchfield
Aug 20, 2014·Frontiers in Computational Neuroscience·Alexander SchwegmannMartin Egelhaaf
Jun 18, 2014·Frontiers in Computational Neuroscience·Pavel A Puzerey, Roberto F Galán
Jul 30, 2011·PloS One·Lubomir KostalOndrej Pokora
Nov 17, 2011·PloS One·Alexander B NeimanM H Rowe
Apr 8, 2015·PloS One·Jonathan MapelliAlbertino Bigiani
Nov 26, 2014·PLoS Biology·Guilherme Testa-SilvaHuibert D Mansvelder
Apr 15, 2017·PLoS Computational Biology·Vijay Singh, Ilya Nemenman
Jan 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kyle SrivastavaSamuel J Sober
Feb 16, 2013·Perception·John P Frisby, James V Stone
Feb 28, 2013·Network : Computation in Neural Systems·Cyrus P BillimoriaJohn T Birmingham
Oct 28, 2017·PLoS Computational Biology·Kris V Parag, Glenn Vinnicombe
Dec 8, 2017·Reports on Progress in Physics·William Bialek
Aug 30, 2018·Biological cybernetics·Sergej O Voronenko, Benjamin Lindner
Mar 20, 2012·PloS One·Yoav KfirRonen Segev
Dec 19, 2018·ELife·Natalia A GoriounovaHuibert D Mansvelder
Dec 23, 2018·Neural Computation·Christophe GardellaThierry Mora
Feb 6, 2019·ELife·Elaine N Miller, Chet C Sherwood
Feb 5, 2009·Nature Reviews. Neuroscience·Susan J Sara
Sep 12, 2008·Journal of Neurophysiology·Alan D DorvalJerrold L Vitek
Sep 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Zhaohui LiXiaoli Li
Mar 16, 2012·Journal of Neural Engineering·H Rostro-GonzalezT Vieville
Apr 18, 2019·Journal of Neurophysiology·Jong-Hoon NamE H Peterson
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Martin VinckCyriel M A Pennartz
Aug 26, 2014·Physical Review Letters·David J SchwabPankaj Mehta
Oct 30, 2009·Journal of Neurophysiology·Nicolas Y Masse, Erik P Cook
Feb 7, 2019·Virus Evolution·Lei Zhao, Christopher J R Illingworth
Oct 3, 2019·Physical Review. E·Caroline M Holmes, Ilya Nemenman
Jan 14, 2017·Physical Review. E·Sarah Marzen, Simon DeDeo
Sep 12, 2019·Frontiers in Computational Neuroscience·Zonglu He
May 14, 2016·Physical Biology·Li Zhaoping
Dec 10, 2014·PLoS Biology·Claire TangSamuel J Sober

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