Neural control of blood pressure is altered following isolated leg heating in aged humans.

American Journal of Physiology. Heart and Circulatory Physiology
Rachel E EngellandSteven A Romero

Abstract

There is a sustained reduction in arterial blood pressure that occurs in aged adults following exposure to acute leg heating. We tested the hypothesis that acute leg heating would decrease arterial blood pressure in aged adults secondary to sympathoinhibition. We exposed 13 young and 10 aged adults to 45 min of leg heating. Muscle sympathetic nerve activity (radial nerve) was measured before leg heating (preheat) and 30 min after (recovery) and is expressed as burst frequency. Neurovascular transduction was examined by assessing the slope of the relation between muscle sympathetic nerve activity and leg vascular conductance measured at rest and during isometric handgrip exercise performed to fatigue. Arterial blood pressure was well maintained in young adults (preheat, 86 ± 6 mmHg vs. recovery, 88 ± 7 mmHg; P = 0.4) due to increased sympathetic nerve activity (preheat, 16 ± 7 bursts/min vs. recovery, 22 ± 10 bursts/min; P < 0.01). However, in aged adults, sympathetic nerve activity did not differ from preheat (37 ± 5 bursts/min) to recovery (33 ± 6 bursts/min, P = 0.1), despite a marked reduction in arterial blood pressure (preheat, 101 ± 7 mmHg vs. recovery, 94 ± 6 mmHg; P < 0.01). Neurovascular transduction did not differ fro...Continue Reading

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Citations

Oct 20, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Holden W HemingwaySteven A Romero
Jan 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Benjamin E YoungPaul J Fadel
Sep 13, 2020·Environment International·Robert D MeadeGlen P Kenny
Feb 26, 2021·Journal of Applied Physiology·Michael A FranciscoChristopher T Minson
Apr 2, 2021·Journal of Applied Physiology·Michael M TymkoCraig D Steinback
Jul 15, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sophie LalandeSteven A Romero

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BETA
hormone replacement therapy
enzyme-linked immunosorbent assay

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WinCPRS
JMP Pro

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