PMID: 2502607Jul 1, 1989Paper

Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents

Journal of Neurophysiology
T J CoderreJ D Levine

Abstract

1. This study addressed the contribution of primary afferents, mast cells, and sympathetic efferents to the control of vascular permeability in synovial joints. Extravasation of Evans blue dye into the synovial space was measured by perfusion of the knee joint in the adult rat. Plasma extravasation (PE) was evoked by pharmacologic activation of either unmyelinated primary afferents, mast cells, or sympathetic postganglionic nerve (SPGN) terminals with acute injection of either capsaicin, compound 48/80, or 6-hydroxydopamine (6-OHDA), respectively. In otherwise untreated control rats, acute infusion of capsaicin or compound 48/80 produced a brief increase in vascular permeability; infusion of 6-OHDA produced a larger and more prolonged increase. 2. To evaluate the contribution of an interaction of different cellular elements in the joint to PE, we repeated these experiments in rats pretreated with capsaicin, compound 48/80, or 6-OHDA; administered quercetin; or surgically sympathectomized by excision of the lumbar sympathetic chain. Eliminating unmyelinated afferent nerve terminals by neonatal treatment with capsaicin only reduced the increase in PE produced by acute infusion of capsaicin. Degranulating mast cells by pretreatmen...Continue Reading

Citations

Nov 1, 1992·The Journal of Comparative Neurology·D G Baker, D M McDonald
Jul 1, 1997·Cranio : the Journal of Craniomandibular Practice·P D Palesy
Jun 26, 1999·Microscopy Research and Technique·L M MendellB M Davis
Aug 19, 2000·Psychosomatic Medicine·S LutgendorfD Lubaroff
Jan 28, 2005·The European Journal of Neuroscience·Paul G Green, Jon D Levine
Feb 1, 2007·Arthritis and Rheumatism·Rainer H Straub, Maurizio Cutolo
Aug 19, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·B Romana-Souza, A Monte-Alto-Costa
Oct 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D J Tracey, J S Walker
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·X Y HuaT L Yaksh
Feb 26, 2003·European Journal of Pain : EJP·Hanne MørkRigmor Jensen
Dec 29, 1995·Annals of the New York Academy of Sciences·L J CroffordR L Wilder
Dec 18, 2003·The Journal of Physiology·Frederick Jia-Pei MiaoJon D Levine
May 22, 2010·Zeitschrift für Rheumatologie·R H Straub, A Fassold
Jan 27, 2015·Inflammation·Stanislava StanojevićMirjana Dimitrijević
Feb 25, 2014·Cephalalgia : an International Journal of Headache·Deepak K BhattInger Jansen-Olesen
Nov 1, 1991·Cephalalgia : an International Journal of Headache·J T KellerM J Fritts
Jun 27, 1998·Cephalalgia : an International Journal of Headache·C Waeber
Nov 28, 2001·The European Journal of Neuroscience·P G GreenJ D Levine
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
Jun 19, 2008·Cephalalgia : an International Journal of Headache·A M Harriott, M S Gold
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·H J StrausbaughJ D Levine
Sep 8, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bina Raju, Salah O Ibrahim
Dec 1, 1994·The European Journal of Neuroscience·G R LewinL M Mendell
May 31, 1993·Annals of the New York Academy of Sciences·A Catania, J M Lipton
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P W AckermannA Kreicbergs

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