Neural control of ventricular rate in ambulatory dogs with pacing-induced sustained atrial fibrillation.

Circulation. Arrhythmia and Electrophysiology
Hyung-Wook ParkPeng-Sheng Chen

Abstract

We hypothesize that inferior vena cava-inferior atrial ganglionated plexus nerve activity (IVC-IAGPNA) is responsible for ventricular rate (VR) control during atrial fibrillation (AF) in ambulatory dogs. We recorded bilateral cervical vagal nerve activity (VNA) and IVC-IAGPNA during baseline sinus rhythm and during pacing-induced sustained AF in 6 ambulatory dogs. Integrated nerve activities and average VR were measured every 10 seconds over 24 hours. Left VNA was associated with VR reduction during AF in 5 dogs (from 211 bpm [95% CI, 186-233] to 178 bpm [95% CI, 145-210]; P<0.001) and right VNA in 1 dog (from 208 bpm [95% CI, 197-223] to 181 bpm [95% CI, 163-200]; P<0.01). There were good correlations between IVC-IAGPNA and left VNA in the former 5 dogs and between IVC-IAGPNA and right VNA in the last dog. IVC-IAGPNA was associated with VR reduction in all dogs studied. Right VNA was associated with baseline sinus rate reduction from 105 bpm (95% CI, 95-116) to 77 bpm (95% CI, 64-91; P<0.01) in 4 dogs, whereas left VNA was associated with sinus rate reduction from 111 bpm (95% CI, 90-1250) to 81 bpm (95% CI, 67-103; P<0.01) in 2 dogs. IVC-IAGPNA is invariably associated with VR reduction during AF. In comparison, right or left...Continue Reading

References

Apr 1, 1988·Physiological Reviews·F L Meijler, M J Janse
Nov 1, 1995·The Journal of Clinical Investigation·J J OngP S Chen
Dec 6, 2002·The New England Journal of Medicine·D G WyseUNKNOWN Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators
Jul 31, 2007·Journal of the American College of Cardiology·Masahiro OgawaPeng-Sheng Chen
Sep 2, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Pietro RossiFabio Miraldi
Dec 2, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mark J ShenPeng-Sheng Chen

❮ Previous
Next ❯

Citations

Jan 29, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Eue-Keun ChoiSeil Oh
Nov 28, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jessica HellyerPeng-Sheng Chen
Dec 19, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Patrick OnkkaPeng-Sheng Chen
Aug 24, 2012·Journal of Cardiovascular Electrophysiology·Youhua ZhangTodor N Mazgalev
Apr 26, 2014·Circulation Research·Peng-Sheng ChenStanley Nattel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.