Neural correlates of a decision variable before learning to perform a match/non-match task.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Xue-Lian QiChristos Constantinidis

Abstract

The lateral prefrontal cortex plays an important role in working memory and decision-making, although little is known about how neural correlates of these functions are shaped by learning. To understand the effect of learning on the neuronal representation of decision-making, we recorded single neurons from the lateral prefrontal cortex of monkeys before and after they were trained to judge whether two stimuli appeared at matching spatial locations. After training, and in agreement with previous studies, a population of neurons exhibited activity that was modulated depending on whether the second stimulus constituted a match or not, which had predictive ability for the monkey's choice. However, even before training, prefrontal neurons displayed modulation depending on the match or non-match status of a stimulus, with approximately equal percentages of neurons preferring a match or a non-match. The difference in firing rate and discriminability for match and non-match stimuli before training was of comparable magnitude as that after training. Changes observed after training involved an increase in the percentage of neurons exhibiting this effect, a greater proportion of neurons preferring non-match stimuli, and a greater percent...Continue Reading

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Citations

Jan 19, 2016·Frontiers in Systems Neuroscience·Mitchell R Riley, Christos Constantinidis
Dec 25, 2012·Behavioural Brain Research·Xue-Lian Qi, Christos Constantinidis
Feb 7, 2015·Frontiers in Psychology·Elisa M TartagliaNicolas Brunel
Apr 14, 2016·ELife·Dmitry KobakChristian K Machens
May 27, 2016·Nature Reviews. Neuroscience·Christos Constantinidis, Torkel Klingberg
Jul 3, 2016·Cerebral Cortex·Mitchell R RileyChristos Constantinidis
Sep 1, 2012·The European Journal of Neuroscience·Xue-Lian Qi, Christos Constantinidis
Sep 19, 2018·Nature Communications·Mitchell R RileyChristos Constantinidis
Mar 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hua TangChristos Constantinidis
Dec 19, 2020·Mechanisms of Ageing and Development·Vasiliki StavroulakiKyriaki Sidiropoulou
Jan 6, 2021·Brain Structure & Function·Mohsen Parto DezfouliMohammad Reza Daliri

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