Neural correlates of action attribution in schizophrenia

Psychiatry Research
C FarrerMarc Jeannerod

Abstract

Patients with first-rank symptoms (FRS) of schizophrenia do not experience all of their actions and personal states as their own. FRS may be associated with an impaired ability to correctly attribute an action to its origin. In the present study, we examined regional cerebral blood flow (rCBF) with positron emission tomography during an action-attribution task in a group of patients with FRS. We used a device previously used with healthy subjects that allows the experimenter to modulate the subject's degree of movement control (and thus action attribution) of a virtual hand presented on a screen. In healthy subjects, the activity of the right angular gyrus and the insula cortex appeared to be modulated by the subject's degree of movement control of the virtual hand. In the present study, the schizophrenic patients did not show this pattern. We found an aberrant relationship between the subject's degree of control of the movements and rCBF in the right angular gyrus and no modulation in the insular cortex. The implications of these results for understanding pathological conditions such as schizophrenia are discussed.

References

Feb 13, 1976·Brain Research·P Müller-Preuss, U Jürgens
Jun 22, 1991·Proceedings. Biological Sciences·C D FrithR S Frackowiak
Jan 1, 1991·Neuropsychologia·C D FrithR S Frackowiak
Sep 1, 1991·The British Journal of Clinical Psychology·R P BentallS Havers
Jun 29, 1981·Brain Research·P Müller-Preuss, D Ploog
Sep 29, 1995·Science·D M WolpertM I Jordan
Aug 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·J SchröderM V Knopp
Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·W GuentherA P Wolf
Jan 19, 1995·Nature
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Frith
Dec 1, 1996·Brain Research. Cognitive Brain Research·C Frith, R Dolan
May 1, 1997·Psychological Medicine·A P Morrison, G Haddock
May 1, 1997·NeuroImage·C J Price, K J Friston
Oct 30, 1998·Psychological Medicine·C A Baker, A P Morrison
Apr 10, 1999·Nature Neuroscience·S J BlakemoreC D Frith
May 4, 1999·Acta Psychiatrica Scandinavica. Supplementum·R J DolanC D Frith
Oct 8, 1999·Journal of Cognitive Neuroscience·S J BlakemoreD M Wolpert
Jan 19, 2000·Trends in Cognitive Sciences·I Gallagher
Mar 17, 2000·Brain Research. Brain Research Reviews·C D FrithD M Wolpert
Nov 4, 2000·The American Journal of Psychiatry·D SimeonM S Buchsbaum
Mar 7, 2001·The American Journal of Psychiatry·N FranckM Jeannerod
Apr 4, 2002·Psychiatry and Clinical Neurosciences·Jürgen L MüllerHelmfried E Klein
Aug 3, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·Nicolas FranckNancy C Andreasen
Apr 2, 2003·Neuropsychologia·S-J BlakemoreC D Frith
Jan 1, 1992·Journal of Psychopharmacology·C D Frith

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Citations

May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gina CaetanoRiitta Hari
May 12, 2007·Schizophrenia Bulletin·Peter Williamson
Mar 7, 2008·Cerebral Cortex·Sophia VinogradovGregory V Simpson
Aug 21, 2008·Brain : a Journal of Neurology·Knut SchnellEuphrosyne Gouzoulis-Mayfrank
Nov 19, 2008·Social Cognitive and Affective Neuroscience·Catherine Preston, Roger Newport
Jan 22, 2009·Schizophrenia Bulletin·Klaas E StephanChris D Frith
Jun 7, 2005·Current Psychiatry Reports·Christine Mohr, Olaf Blanke
Sep 12, 2012·Schizophrenia Research and Treatment·Cynthia Gayle Wible
Jun 1, 2010·Brain Structure & Function·Hans-Otto Karnath, Bernhard Baier
Jun 14, 2006·Journal of Cognitive Neuroscience·Jana Schaich BorgWalter Sinnott-Armstrong
Feb 10, 2009·Journal of Cognitive Neuroscience·Claus LammJean Decety
May 14, 2011·Journal of Cognitive Neuroscience·David B MieleJanet Metcalfe
Oct 8, 2008·Development and Psychopathology·Jean Decety, Meghan Meyer
Jun 1, 2010·Cognitive Neuroscience·Dirk T LeubeTilo T J Kircher
Aug 19, 2008·Experimental Brain Research·Marc Jeannerod
Mar 11, 2010·Experimental Brain Research·Liuba PapeoPatrick Haggard
Dec 29, 2010·Experimental Brain Research·Christian DohleHans-Joachim Freund
Jul 15, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Bauke M de Jong
Nov 20, 2010·Consciousness and Cognition·Mauricio Sierra, Anthony S David
May 5, 2009·Neuroscience Letters·Kyung-Min ParkKang-Jun Yoon
Apr 3, 2009·Psychiatry Research·Flavie Waters, Assen Jablensky
Dec 9, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sally EastonChristine Mohr
Apr 22, 2008·Consciousness and Cognition·Nicole DavidKai Vogeley
Mar 3, 2009·L'Encéphale·C Farrer, N Franck
Jun 10, 2008·Neurophysiologie clinique = Clinical neurophysiology·C LopezO Blanke
Oct 9, 2007·Consciousness and Cognition·Lars Schwabe, Olaf Blanke
Apr 10, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·M NagaiS Kato
May 29, 2007·Comptes rendus biologies·Andrés PosadaMarc Jeannerod
Jul 3, 2009·Journal of Clinical Psychology·Benjamin Brent
Dec 21, 2010·Acta Psychiatrica Scandinavica·F WatersA Jablensky
Apr 13, 2011·Human Brain Mapping·Corrado Corradi-Dell'AcquaPaolo Brambilla
Jun 12, 2012·Developmental Cognitive Neuroscience·Jean Decety, Margarita Svetlova
Nov 8, 2006·Psychiatry Research·Eric Brunet-Gouet, Jean Decety
Nov 1, 2005·Consciousness and Cognition·Pascal BoyerAnthony I Jack

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