Neural Correlates of Cardiac Interoceptive Focus Across Development: Implications for Social Symptoms in Autism Spectrum Disorder.

Autism Research : Official Journal of the International Society for Autism Research
M. D. FaillaCarissa J Cascio

Abstract

Interoception involves the processing of sensory information relevant to physiological functioning and is integral to building self-awareness, emotional states, and modulating social behaviors. With the role of interoception in emotional processing and social functioning, there is growing interest in characterizing interoception in autism spectrum disorder (ASD), yet, there are mixed results regarding cardiac interoceptive accuracy in ASD. In this study, we explored the neural basis of cardiac interoception using an fMRI heartbeat-counting task in order to assess neural correlates of primary interoception. We predicted that interoceptive-specific response in the insula, a "hub" for interoception, would be related to ASD symptomatology. We investigated the relationship of insula responses during cardiac interoceptive focus and a self/caregiver-reported autism-related symptom scale (Social Responsiveness Scale-2 (SRS)). Participants included 46 individuals with autism spectrum disorder (ASD) (age 8-54, mean = 19.43 ± 10.68 years) and 54 individuals with typical development for comparison (TC, age 8-53, mean = 21.43 ± 10.41 years). We found no significant difference in cardiac interoceptive accuracy or neural response to cardiac i...Continue Reading

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Citations

Jul 16, 2021·Journal of Autism and Developmental Disorders·Han-Xue YangRaymond C K Chan
Jul 22, 2021·Journal of Autism and Developmental Disorders·Han-Xue YangRaymond C K Chan
Aug 7, 2021·Neuroscience and Biobehavioral Reviews·Rebecca BrewerGeoffrey Bird

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