Neural correlates of changes in sexual function in frontotemporal dementia: implications for reward and physiological functioning

Journal of Neurology
Rebekah M AhmedMuireann Irish

Abstract

Frontotemporal dementia (FTD) is characterised by changes in behaviour including alterations in sexual function. While hypersexual behaviour is commonly thought to predominate, emerging evidence suggests that hyposexual behaviour is in fact most prevalent. The underlying mechanisms driving these behavioural changes remain unclear; however, likely reflect interactions between cognitive, emotional, reward processing and physiological functioning. We aimed to systematically quantify changes in sexual behaviour in behavioural variant FTD (bvFTD) and semantic dementia (SD) in contrast with Alzheimer's disease (AD) and to elucidate the neural correlates of these changes using whole-brain voxel-based morphometry. Carers of 62 dementia patients (30 bvFTD, 12 SD, 20 AD) were interviewed using the Sexual Behaviour and Intimacy Questionnaire, which assesses changes in sexual function. Voxel-based morphometry analysis of structural MRI brain scans was used to determine the association between changes in grey matter intensity and the presence of hyposexual, hypersexual, and inappropriate sexual behaviour across groups. Widespread attenuation of sexual drive, intimacy and the display of affection were evident irrespective of dementia subtype...Continue Reading

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Citations

Aug 29, 2019·Annals of Clinical and Translational Neurology·Rebekah M AhmedOlivier Piguet
Sep 14, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Raffaella MigliaccioRichard Levy
Apr 10, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Halle QuangFiona Kumfor

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