Neural correlates of cognitive function and symptoms in attention-deficit/hyperactivity disorder in adults

NeuroImage. Clinical
Kuaikuai DuanJingyu Liu

Abstract

While gray matter (GM) anomalies have been reported for attention-deficit/hyperactivity disorder (ADHD), investigating their associations with cognitive deficits and individual symptom domains can help pinpoint the neural underpinnings critical for the pathology of ADHD, particularly the persist form of ADHD. In this work, we performed both independent component analysis and voxel-based morphometry analysis on whole brain GM of 486 adults including 214 patients, 96 unaffected siblings, and 176 healthy controls, in relation to cognition and symptoms. Independent component analysis revealed that higher GM volume in inferior semilunar lobule, inferior frontal gyri, and superior and middle frontal gyri was associated with better working memory performance, and lower GM volume in cerebellar tonsil and culmen was associated with more severe inattention symptoms. Consistently, voxel-based morphometry analysis showed that higher GM volume in multiple regions of frontal lobe, cerebellum and temporal lobe was related to better working memory performance. Focusing on the networks derived from ICA, our results integrated prefrontal regions and cerebellar regions through associations with working memory and inattention symptoms, lending sup...Continue Reading

Citations

May 1, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C E M FernandesR Mattioli
May 23, 2019·Psychological Medicine·Huey-Ling ChiangSusan Shur-Fen Gau
Nov 23, 2019·Journal of Neurodevelopmental Disorders·Lauren M McGrath, Catherine J Stoodley
Mar 17, 2021·International Clinical Psychopharmacology·Lenard A AdlerAntony Loebel
Mar 30, 2021·Psychiatry Research. Neuroimaging·Wenhao JiangJessica A Turner
Feb 10, 2021·Harvard Review of Psychiatry·Alan A Baumeister

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IMpACT
SPM12
GIFT
NeuroIMAGE
Statistical Parametric Mapping
Infomax
ICASSO

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