Abstract
Compulsive alcohol use, the tendency to continue alcohol seeking and taking despite negative consequences, is a hallmark of alcohol use disorder. Preclinical rodent studies have suggested a role for the medial prefrontal cortex, anterior insula, and nucleus accumbens in compulsive alcohol seeking. It is presently unknown whether these findings translate to humans. We used a novel functional magnetic resonance imaging paradigm and tested the hypothesis that heavy drinkers would compulsively seek alcohol despite the risk of an aversive consequence, and that this behavior would be associated with the activity of frontostriatal circuitry. Non-treatment-seeking heavy and light drinkers (n = 21 per group) completed a functional magnetic resonance imaging paradigm in which they could earn alcohol or food points at various threat levels (i.e., various probabilities of incurring an aversive consequence). Brain function was evaluated when individuals had the opportunity to earn reward points at the risk of an aversive consequence, an electric shock on the wrist. Compared with light drinkers, heavy drinkers attempted to earn more aversion-paired alcohol points. Frontostriatal circuitry, including the medial prefrontal cortex, anterior ins...Continue Reading
Citations
Mar 26, 2019·PLoS Biology·Meiling LiHesheng Liu
Sep 10, 2019·Addiction·Christina J Perry, Andrew J Lawrence
Sep 27, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Erica N GrodinLara A Ray
Aug 23, 2019·Addiction Biology·Hu Chen, Amy W Lasek
Nov 23, 2019·Science·Kimberly Nixon, Regina A Mangieri
Sep 29, 2020·Frontiers in Neural Circuits·Hang-Bin ZhangDi Zhao
May 30, 2019·Frontiers in Behavioral Neuroscience·Elisabetta BurchiEric Hollander
Dec 18, 2020·Frontiers in Behavioral Neuroscience·Mia HaaranenPetri Hyytiä
Dec 10, 2019·Drug and Alcohol Dependence·Lara A RayKate Wassum
Jan 25, 2021·Journal of Neurochemistry·Erin J Campbell, Andrew J Lawrence
Jun 17, 2020·Behavioural Brain Research·David Darevsky, Frederic W Hopf
May 1, 2021·International Journal of Molecular Sciences·Anna K RadkeFrederic W Hopf
Jun 3, 2021·Journal of Clinical Medicine·Olga Hernández-SerranoJosé Gutiérrez-Maldonado
Aug 20, 2021·Science Advances·Esi DomiMarkus Heilig