Neural correlates of hallucinations in bipolar disorder

Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina
Maila de C NevesHumberto Corrêa

Abstract

Approximately one-half of all patients affected by bipolar disorder present with psychotic features on at least one occasion. Several studies have found that alterations in the activity of mesolimbic and prefrontal regions are related to aberrant salience in psychotic patients. The aim of the present study was to investigate the structural correlates of a history of hallucinations in a sample of euthymic patients with bipolar I disorder (BD-I). The sample consisted of 21 euthymic patients with BD-I and no comorbid axis I DSM-IV-TR disorders. Voxel based morphometry (VBM) was used to compare patients with and without a lifetime history of hallucinations. Preprocessing was performed using the Diffeomorphic Anatomical Registration through Exponentiated Lie Algebra (DARTEL) algorithm for VBM in SPM8. Images were processed using optimized VBM. The main finding of the present study was a reduction in gray matter volume in the right posterior insular cortex of patients with BD-I and a lifetime history of hallucinations, as compared to subjects with the same diagnosis but no history of hallucinations. This finding supports the presence of abnormalities in the salience network in BD patients with a lifetime history of hallucinations. Th...Continue Reading

References

Aug 1, 1988·Archives of General Psychiatry·J B Williams
Aug 2, 2001·The American Journal of Psychiatry·J B PotashM G McInnis
Nov 13, 2002·Cerebral Cortex·Jane ShapleskeAnthony S David
Aug 19, 2003·Comprehensive Psychiatry·Paul E KeckRobert M Post
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Apr 28, 2006·CNS Spectrums·Caleb M AdlerStephen M Strakowski
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Apr 10, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·M NagaiS Kato
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nico U F DosenbachSteven E Petersen
Sep 1, 2007·NeuroImage·John Ashburner
Aug 16, 2008·CNS Spectrums·Wayne C DrevetsMichael Trimble
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Oct 16, 2008·Brain : a Journal of Neurology·Iris E C SommerRené S Kahn
Dec 17, 2008·Human Brain Mapping·Keri S TaylorKaren D Davis
Mar 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tsutomu TakahashiChristos Pantelis
Sep 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew J KemptonSophia Frangou
Jan 15, 2010·Schizophrenia Research·Ian Ellison-Wright, Ed Bullmore
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jun 1, 2010·Brain Structure & Function·Hans-Otto Karnath, Bernhard Baier
Oct 19, 2010·The American Journal of Psychiatry·Renaud JardriPierre Thomas
Dec 15, 2010·Psychological Medicine·L PalaniyappanP F Liddle
Feb 16, 2011·Molecular Psychiatry·K MatsuoJ C Soares
Jun 23, 2011·Journal of Psychiatry & Neuroscience : JPN·Lena Palaniyappan, Peter F Liddle
Feb 3, 2012·Journal of Psychiatry & Neuroscience : JPN·Andrée M CusiMargaret C McKinnon
Nov 14, 2012·Psychiatry Research·Victoria B GradinJ Douglas Steele
Nov 10, 2013·Psychiatry Research·Daniele RadaelliFrancesco Benedetti

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

Matlab
SPSS
MINI
Statistical Parametric Mapping

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists
Paul Dignam
Nursing Times
C M Wallace
Scientific American
R K Siegel
© 2022 Meta ULC. All rights reserved