Neural correlates of isometric force in the "motor" thalamus

Experimental Brain Research
R Anner-BarattiM C Hepp-Reymond

Abstract

The relationship between single cell activity in the "motor" thalamus and the generation of isometric force between the fingers has been investigated in 2 monkeys. Neurons related to the task were found in the thalamic motor regions VLo, VPLo, and VA where microstimulation occasionally elicited motor reactions in hand and fingers. 58% of these 55 neurons, designated "typical", showed modulation of their discharge patterns with force similar to neurons in precentral cortex and could be assigned to one of 5 discharge patterns described for the motor cortex. Only a small percentage of the thalamic neurons were found to have phasic activity. The other "atypical" neurons (42%) had discharge patterns with complex sequences of phasic and tonic activation with respect to force. For 18 typical and atypical neurons with tonic and phasic-tonic modulation of their firing rate with force significant regression coefficients between firing rate and static force were observed. The mean index of force sensitivity (rate-force slope) was 54.5 Hz/N for the neurons increasing their discharge rate with force, i.e. approximately that of precentral cells. Neurons tested for their sensory properties had receptive fields located on hand and/or fingers a...Continue Reading

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