Neural correlates of movement preparation in healthy ageing

The European Journal of Neuroscience
Annette Sterr, Philip Dean

Abstract

Motor disorders increase dramatically with age; however, little is known about non-clinical ageing of motor control mechanisms and their respective neural correlates. With the present experiment we aimed to study age effects on advance movement preparation, a key characteristic of motor behaviour that is known to involve premotor and primary motor circuits. The respective brain regions are subject to age-related brain atrophy of grey and white matter, and we therefore hypothesized that motor preparation mechanisms may be altered in older persons. Using a motor priming paradigm, performance data and event-related potentials were recorded in older (68-83 years) and younger (21-25 years) participants. The effect pattern observed for the younger group fully replicated previous findings, showing significant reaction time benefits and greater foreperiod activity for valid trials, as well as lateralized activation over motor regions. In older participants, the validity effect was insignificant, which corresponded to markedly reduced foreperiod amplitudes and the absence of lateralized activity. At the same time, the event-related potential showed a frontocentrally distributed positive component peaking in the P300 latency range after ...Continue Reading

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Citations

Apr 27, 2011·Brain Topography·Michael J FalvoGammon M Earhart
May 2, 2012·Neural Plasticity·Annette Sterr, Adriana Bastos Conforto
Jun 6, 2014·Journal of Ophthalmology·Wendy E HuddlestonKevin G Keenan
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Feb 27, 2019·Psychological Research·Paola MengottiSimone Vossel
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Sep 16, 2011·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Jos J AdamPascal W M Van Gerven
Jun 24, 2017·Journal of Bone Metabolism·Young Nam Kwon, Sung Sang Yoon
Apr 8, 2011·Psychophysiology·Hakuei FujiyamaJeffery J Summers
May 6, 2015·Neuropsychologia·Patrick D Gajewski, Michael Falkenstein

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