Neural correlates of prenatal stress in young women

Psychological Medicine
A FavaroP Santonastaso

Abstract

Prenatal stress is hypothesized to have a disruptive impact on neurodevelopmental trajectories, but few human studies have been conducted on the long-term neural correlates of prenatal exposure to stress. The aim of this study was to explore the relationship between prenatal stress exposure and gray-matter volume and resting-state functional connectivity in a sample of 35 healthy women aged 14-40 years. Voxel-based morphometry and functional connectivity analyses were performed on the whole brain and in specific regions of interest (hippocampus and amygdala). Data about prenatal/postnatal stress and obstetric complications were obtained by interviewing participants and their mothers, and reviewing obstetric records. Higher prenatal stress was associated with decreased gray-matter volume in the left medial temporal lobe (MTL) and both amygdalae, but not the hippocampus. Variance in gray-matter volume of these brain areas significantly correlated with depressive symptoms, after statistically adjusting for the effects of age, postnatal stress and obstetric complications. Prenatal stress showed a positive linear relationship with functional connectivity between the left MTL and the pregenual cortex. Moreover, connectivity between t...Continue Reading

References

Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Jan 1, 1974·Behavioral Science·L R DerogatisL Covi
Jul 8, 2000·Schizophrenia Bulletin·S L BukaM T Tsuang
Jul 13, 2000·Archives of General Psychiatry·M M WeissmanM Olfson
May 7, 2003·Neuroscience and Biobehavioral Reviews·Martin H TeicherDennis M Kim
Jul 5, 2003·Physiological Reviews·P SahJ Power
Sep 18, 2004·Science·Peter D Gluckman, Mark A Hanson
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jan 4, 2006·Archives of General Psychiatry·Angela FavaroPaolo Santonastaso
Apr 22, 2008·Neuroscience and Biobehavioral Reviews·Marta Weinstock
Feb 19, 2009·Schizophrenia Bulletin·S Hossein Fatemi, Timothy D Folsom
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
Jun 17, 2010·Brain Research Reviews·Arnaud CharilSuzanne King
Sep 22, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Elysia Poggi DavisCurt A Sandman
Jan 5, 2011·European Archives of Psychiatry and Clinical Neuroscience·Angela FavaroPaolo Santonastaso
Mar 1, 2011·NeuroImage·Brian PatenaudeMark Jenkinson
Sep 6, 2011·Journal of Affective Disorders·Julia SacherMatthias L Schroeter
Oct 28, 2011·Nature·Hyo Jung KangNenad Sestan
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Jian LiBerthold Hocher
Apr 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Claudia BussCurt A Sandman
Aug 8, 2012·The Journal of Clinical Endocrinology and Metabolism·Nina AlexanderClemens Kirschbaum
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bryan KolbRobbin Gibb
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kristine B WalhovdUNKNOWN Pediatric Imaging, Neurocognition, and Genetics Study
Feb 13, 2013·Biological Psychiatry·Bart de KwaastenietDamiaan Denys
Feb 20, 2013·Schizophrenia Bulletin·Unn K HaukvikIngrid Agartz
Apr 25, 2013·Biological Psychiatry·Elysia Poggi DavisKevin Head
Jul 16, 2013·Neuroscience and Biobehavioral Reviews·Marco CataniMichel Thiebaut de Schotten
Dec 7, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David PagliaccioDeanna M Barch
Feb 28, 2014·Frontiers in Neuroscience·Andrea SchmittPeter Falkai
Aug 19, 2014·Biological Psychiatry·Curt A SandmanElysia Poggi Davis

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Citations

Nov 3, 2016·Pediatric Research·Dustin ScheinostLaura R Ment
Aug 3, 2018·Development and Psychopathology·Bea R H van den BerghMaarten Mennes
May 28, 2019·International Journal of Environmental Research and Public Health·Laura S BlekerSusanne R de Rooij
Aug 31, 2019·Stress : the International Journal on the Biology of Stress·Markus HermesMatthias Schwab
May 7, 2020·Current Pharmaceutical Design·Giulia LisiCinzia Niolu
May 11, 2019·Child Development·Elysia Poggi DavisCurt A Sandman
Mar 20, 2018·Scientific Reports·Klára MarečkováMilan Brázdil
Sep 30, 2019·Developmental Psychobiology·Carolien Konijnenberg, Annika Melinder
Feb 1, 2020·Neuroscience and Biobehavioral Reviews·Katja FrankeMatthias Schwab
Apr 28, 2021·Progress in Neurobiology·Navneet A Vasistha, Konstantin Khodosevich
Aug 2, 2017·Neuroscience and Biobehavioral Reviews·Bea R H Van den BerghMatthias Schwab
Jun 15, 2021·Neurobiology of Stress·Zahra RezaeiMajid H Mohajerani
Aug 7, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Klara MareckovaYuliya S Nikolova

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