Neural correlates of the chronic fatigue syndrome--an fMRI study

Brain : a Journal of Neurology
Floris P de LangeIvan Toni

Abstract

Chronic fatigue syndrome (CFS) is characterized by a debilitating fatigue of unknown aetiology. Patients who suffer from CFS report a variety of physical complaints as well as neuropsychological complaints. Therefore, it is conceivable that the CNS plays a role in the pathophysiology of CFS. The purpose of this study was to investigate neural correlates of CFS, and specifically whether there exists a linkage between disturbances in the motor system and CFS. We measured behavioural performance and cerebral activity using rapid event-related functional MRI in 16 CFS patients and 16 matched healthy controls while they were engaged in a motor imagery task and a control visual imagery task. CFS patients were considerably slower on performance of both tasks, but the increase in reaction time with increasing task load was similar between the groups. Both groups used largely overlapping neural resources. However, during the motor imagery task, CFS patients evoked stronger responses in visually related structures. Furthermore, there was a marked between-groups difference during erroneous performance. In both groups, dorsal anterior cingulate cortex was specifically activated during error trials. Conversely, ventral anterior cingulate co...Continue Reading

Citations

Mar 16, 2006·Experimental Brain Research·Marcel MutsaartsHarold Bekkering
Dec 19, 2008·Psychological Medicine·Floris P De LangeIvan Toni
Dec 15, 2007·Journal of the International Neuropsychological Society : JINS·Erin D Bigler
Dec 27, 2005·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·A St Clair GibsonT D Noakes
Apr 14, 2006·Current Opinion in Psychiatry·Hyong Jin ChoSimon Wessely
Sep 30, 2009·Neuroreport·Masahiko NishimuraShogo Ishiuchi
Mar 1, 2006·BMC Neurology·Masaaki TanakaYasuyoshi Watanabe
Jun 6, 2009·BioPsychoSocial Medicine·Christopher BurtonGijs Bleijenberg
Aug 28, 2010·Psychiatry Research·Filip Van Den EedeBernard G C Sabbe
Mar 13, 2010·The British Journal of Radiology·R PerrinA Jackson
Mar 14, 2009·Somatosensory & Motor Research·W FreundA P Wunderlich
Mar 21, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Philip M UllrichDedra Buchwald
Oct 9, 2009·Journal of Pain and Symptom Management·Anners LerdalHesook S Kim
Jun 28, 2005·Gastroentérologie Clinique Et Biologique·Thierry PicheAlbert Tran
Apr 5, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Floris P de LangeIvan Toni
Mar 16, 2007·Médecine et maladies infectieuses·T Papo
Apr 11, 2007·Acta Neurologica Scandinavica. Supplementum·Vegard Bruun Wyller
Nov 25, 2011·Human Brain Mapping·Cathérine C S DelnoozIvan Toni
May 10, 2011·Brain Research·Masaaki Tanaka, Yasuyoshi Watanabe
Jan 12, 2013·Behavioral and Brain Functions : BBF·Yoshihito ShigiharaYasuyoshi Watanabe
Sep 4, 2007·Brain Research·Biba R StantonAndrew Simmons
Sep 19, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L D Devanur, J R Kerr
Sep 9, 2006·NeuroImage·Floris P de LangeIvan Toni
Aug 29, 2006·Sleep Medicine·Christian GuilleminaultMaria Cecilia Lopes
Jun 16, 2005·NeuroImage·Floris P de LangeIvan Toni
Nov 2, 2011·Neuroscience and Biobehavioral Reviews·Masaaki Tanaka, Yasuyoshi Watanabe
Sep 27, 2008·Journal of Affective Disorders·D SchrijversB G C Sabbe
Apr 21, 2010·Journal of Psychosomatic Research·Hans KnoopGijs Bleijenberg
Dec 30, 2014·Frontiers in Behavioral Neuroscience·Djamila BennabiCharalambos Papaxanthis
Jun 17, 2014·Fatigue : Biomedicine, Health & Behavior·David Benjamin FischerJordan D Dimitrakoff
Apr 29, 2016·Journal of Magnetic Resonance Imaging : JMRI·Zack Y ShanLeighton R Barnden
Nov 8, 2016·Biological Psychiatry·Marieke E van der SchaafHans Knoop
Sep 21, 2016·Journal of Clinical and Experimental Neuropsychology·Laura Anne WortingerVegard Bruun Wyller
Sep 30, 2016·Clinical Physiology and Functional Imaging·Jeff BoissoneaultRoland Staud

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