Neural Correlates of the Cortisol Awakening Response in Humans

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Andreas BoehringerAndreas Meyer-Lindenberg

Abstract

The cortisol rise after awakening (cortisol awakening response, CAR) is a core biomarker of hypothalamic-pituitary-adrenal (HPA) axis regulation related to psychosocial stress and stress-related psychiatric disorders. However, the neural regulation of the CAR has not been examined in humans. Here, we studied neural regulation related to the CAR in a sample of 25 healthy human participants using an established psychosocial stress paradigm together with multimodal functional and structural (voxel-based morphometry) magnetic resonance imaging. Across subjects, a smaller CAR was associated with reduced grey matter volume and increased stress-related brain activity in the perigenual ACC, a region which inhibits HPA axis activity during stress that is implicated in risk mechanisms and pathophysiology of stress-related mental diseases. Moreover, functional connectivity between the perigenual ACC and the hypothalamus, the primary controller of HPA axis activity, was associated with the CAR. Our findings provide support for a role of the perigenual ACC in regulating the CAR in humans and may aid future research on the pathophysiology of stress-related illnesses, such as depression, and environmental risk for illnesses such as schizophre...Continue Reading

References

Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R A DressendörferC J Strasburger
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Aug 12, 2000·Psychoneuroendocrinology·S WüstC Kirschbaum
Feb 13, 2001·Journal of Psychiatric Research·P D PatelA F Schatzberg
Jan 3, 2003·Psychoneuroendocrinology·M BartelsE J C de Geus
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Dec 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Maureen P BoyleLouis J Muglia
May 14, 2005·Nature Reviews. Neuroscience·E Ron de KloetFlorian Holsboer
Jun 14, 2005·Psychoneuroendocrinology·Nina KupperGonneke Willemsen
Sep 13, 2005·Psychoneuroendocrinology·Michèle WessaHerta Flor
Nov 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·James P HermanHelmer Figueiredo
Mar 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andreas Meyer-LindenbergDaniel R Weinberger
Apr 18, 2006·Biological Psychiatry·Ronald A CohenLeanne M Williams
May 19, 2006·Psychoneuroendocrinology·Thomas J HuberOliver T Wolf
May 30, 2006·Neuroscience and Biobehavioral Reviews·Anke KarlAnnett Werner
Apr 4, 2007·The American Journal of Psychiatry·Zola N ManniePhilip J Cowen
Apr 6, 2007·Psychoneuroendocrinology·Ines WilhelmStefan Wüst
Dec 8, 2007·Trends in Neurosciences·Marian JoëlsE Ronald de Kloet
Aug 5, 2008·Trends in Neurosciences·Carmine M Pariante, Stafford L Lightman
Nov 22, 2008·Biological Psychology·Yoichi Chida, Andrew Steptoe
Jan 7, 2009·Archives of General Psychiatry·Christine HeimWilliam C Reeves
May 27, 2009·Nature Reviews. Neuroscience·Yvonne M Ulrich-Lai, James P Herman
Jun 3, 2009·Archives of General Psychiatry·Sophie A VreeburgBrenda W J H Penninx
Sep 25, 2010·Biological Psychiatry·Katarina DedovicJens C Pruessner
Dec 15, 2010·Biological Psychiatry·Clement HamaniAndres M Lozano
Dec 21, 2010·Trends in Cognitive Sciences·Amit EtkinRaffael Kalisch
Jun 24, 2011·Nature·Florian LederbogenAndreas Meyer-Lindenberg
Nov 15, 2011·Schizophrenia Bulletin·Paolo Fusar-PoliStefan Borgwardt
Feb 9, 2012·Nature Medicine·Heike Tost, Andreas Meyer-Lindenberg
Apr 17, 2012·Nature Neuroscience·Andreas Meyer-Lindenberg, Heike Tost

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Citations

Jan 9, 2016·Social Cognitive and Affective Neuroscience·Nathalie E HolzManfred Laucht
May 28, 2016·Neuroscience and Biobehavioral Reviews·Maximus BergerZoltán Sarnyai
Feb 1, 2017·Scientific Reports·Maximus BergerZoltán Sarnyai
Jun 14, 2018·Expert Review of Neurotherapeutics·Jean Schoenen, Gianluca Coppola
Sep 26, 2019·Psychiatry Investigation·Chien-Han Lai
Oct 20, 2019·Molecular Psychiatry·Nathalie E HolzAndreas Meyer-Lindenberg
Feb 20, 2020·Stress : the International Journal on the Biology of Stress·S KetheesanZ Sarnyai
Jan 6, 2017·Schizophrenia Bulletin·Jean-Paul SeltenAndreas Meyer-Lindenberg
May 23, 2017·Journal of Circadian Rhythms·Isaac ChayoJaime L Tartar
Jan 12, 2019·Journal of Neural Transmission·Hannes NoackBirgit Derntl
Mar 25, 2017·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Antonio F GarciaDeborah L Mangold
Dec 29, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chien-Han Lai
Jan 26, 2021·Psychoneuroendocrinology·Travis AndersonSuzanne Vrshek-Schallhorn

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