Neural correlates of variable working memory load across adult age and skill: dissociative patterns within the fronto-parietal network

Scandinavian Journal of Psychology
Lars NybergLars Bäckman

Abstract

We examined neural changes related to variations in working memory load by using an n-back task with three levels and functional magnetic resonance imaging. Younger adults were divided into high- and low-performing groups (Young-High; Young-Low) and compared with older adults. Relative to Young-High, capacity-constraints in working memory were apparent between load 1-2 for the elderly and between load 2-3 for Young-Low. Capacity-constraints in neural activity followed this pattern by showing a monotonically increasing response in parietal cortex and thalamus for Young-High, whereas activity leveled off at 1-back for the elderly and at 2-back for Young-Low. The response in dorsal frontal cortex followed a similar pattern with the addition that the magnitude of activation differed within capacity limitations (Old > Young at 1-back; Young-Low > Young-High at 2-back). These findings indicate that an important determinant of WM capacity is the ability to keep the frontal cortex adequately engaged in relation to current task demands.

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Citations

Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Irene E NagelHauke R Heekeren
Sep 11, 2010·Journal of Cognitive Neuroscience·Irene E NagelHauke R Heekeren
Nov 19, 2013·Journal of Cognitive Neuroscience·Lars NybergLars-Göran Nilsson
Feb 5, 2016·Brain Imaging and Behavior·Anouk VermeijJurgen A H R Claassen
Dec 22, 2010·Brain Research·Juan-Carlos BustamanteCésar Avila
Dec 23, 2009·Neuroscience and Biobehavioral Reviews·Lars BäckmanLars Nyberg
Oct 9, 2015·Neuron·Johan ErikssonLars Nyberg
Nov 10, 2015·BioMed Research International·Anna-Mariya KirovaSarita Lagalwar
Apr 6, 2016·NeuroImage·Stephan HeinzelChristine Stelzel
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Jul 16, 2011·NeuroImage·Yvonne BrehmerLars Bäckman
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Jun 15, 2018·Cerebral Cortex·Alireza SalamiLars Nyberg
Jan 17, 2020·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Kara L Bopp, Paul Verhaeghen
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Nov 22, 2018·Frontiers in Aging Neuroscience·Maki SuzukiKaoru Sekiyama
Jan 23, 2018·Scandinavian Journal of Psychology·Lars Nyberg
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May 29, 2021·Journal of Neuroscience Research·Lídia Vaqué-AlcázarDavid Bartrés-Faz

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