PMID: 2499978Jan 1, 1989Paper

Neural crest origin of clear cell sarcoma of tendons and aponeuroses. Ultrastructural and enzyme cytochemical study of human and nude mouse-transplanted tumours

Virchows Archiv. A, Pathological Anatomy and Histopathology
Y MiiT Yamanouchi

Abstract

In order to clarify the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS), two cases of human and one nude mouse-transplanted CCS line were studied using an ultrastructural and enzyme cytochemical approach. Most of the tumour cells obtained from the primary and transplanted CCS demonstrated melanosomes in various stages of development within the cytoplasm, whereas no melanosomes could be identified in the metastatic CCS. However, cholinesterase and tyrosinase activities could be demonstrated not only in the melanotic primary and transplanted CCS but also in the amelanotic metastatic CCS. The results therefore support the hypothesis that CCS is a soft tissue tumour derived from the neural crest.

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Citations

Aug 10, 2004·Cancer Science·Tomonari TakahiraMasazumi Tsuneyoshi
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M LopesM Sobrinho-Simões
Jun 13, 2019·Oncology Letters·Keisuke KawashimaTamotsu Takeuchi
Jan 12, 2021·The Journal of Pathology·Sarmishta KannanKevin B Jones
May 22, 2021·Cell Death & Disease·Manuel Pedro Jimenez-GarcíaAmancio Carnero

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