PMID: 5123259Oct 1, 1971Paper

Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreas

A G Pearse, J M Polak


A method of labelling known to be appropriate for the demonstration of endocrine polypeptide (APUD) cells was found to label the cells of the neural crest in the chick embryo after as little as 72 hours' development. The method depends on the production, from an exogenous precursor, of an amine which is stored in specific granules and which is convertible by treatment with hot formaldehyde vapour into a fluorescent derivative. The whole technique is described as APUD-FIF. The application of APUD-FIF to mouse embryos shows that at the 7-8 somite stage (eight days) labelled neural crest cells migrate in large masses in a ventrad direction. At around the ninth day they colonize the developing foregut and its derivatives, including pharynx, stomach, duodenum, ultimobranchial body, and pancreas. In subsequent stages of development (up to 12 days) the cells are seen in comparatively large numbers in the gastrointestinal tract and in the pancreas. Complete proof that these early APUD cells, which demonstrably arise from the neural crest, are the precursors of all the endocrine polypeptide cells of the adult pancreas, stomach, duodenum, and small and large intestine, is not at present available. Notwithstanding a great deal of earlier ...Continue Reading


Jan 1, 1971·Histochemie. Histochemistry. Histochimie·A G Pearse, J M Polak
Jan 1, 1967·Annual Review of Pharmacology·O Eränkö
Feb 1, 1971·General and Comparative Endocrinology·J M PolakA G Pearse
Mar 1, 1969·Scientific American·N K Wessells, W J Rutter
Apr 1, 1951·The American Journal of the Medical Sciences·H BEERMAN

❮ Previous
Next ❯


Jan 30, 1999·The Journal of Pathology·A AndrewB B Rawdon
Apr 1, 1997·Microscopy Research and Technique·D W Scheuermann
Apr 30, 1999·The Prostate·P A Abrahamsson
Dec 1, 1990·Journal of Surgical Oncology·J O NwilohH P Freeman
Sep 1, 1993·Seminars in Surgical Oncology·M K McLeodB Shapiro
Jan 17, 1978·European Journal of Pediatrics·K BeckerH J Bremer
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·H D GrayC H Horne
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·J ChenC L Berry
May 1, 1977·The American Journal of Digestive Diseases·W Domschke
Jan 1, 1974·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A G PearseC M Heath
Nov 1, 1991·Irish Journal of Medical Science·E E MooneyP A Dervan
Sep 26, 2012·Pediatric Surgery International·Simon KarglWolfgang Pumberger
Aug 13, 2011·Pathology Oncology Research : POR·Asmaa Gaber AbdouMarwa Dawoud
Nov 30, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·I P KemaF A Muskiet
Jan 1, 1985·Seminars in Roentgenology·W J DoddsW D Foley
May 1, 1990·Peptides·J G McCoy, D D Avery
May 28, 1990·Molecular and Cellular Endocrinology·P J RussellD Raghavan
Mar 8, 1985·Biochimica Et Biophysica Acta·D LeRoithJ Shiloach
Jun 15, 1973·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N S Track
Jun 1, 1977·The Annals of Thoracic Surgery·L H Smith
Dec 1, 1987·Pathology, Research and Practice·F WarsonO Peters
Oct 31, 2003·Clinical Imaging·Francesca MaccioniMario Marini
Apr 6, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Juan Rosai
Feb 1, 1997·Acta Physiologica Scandinavica·K TømmeråsS Mårdh
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P RobberechtJ J Vanderhaeghen
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Oct 1, 1975·Annals of Surgery·S R Friesen, J E McGuigan
Jan 1, 1976·Clinical Endocrinology·A G Pearse, T T Takor
Sep 1, 1977·Histopathology·F C Ho, J C Ho
Dec 1, 1977·International Journal of Dermatology·R J Reed
Mar 1, 1977·Acta Pathologica Japonica·A KawaoiT Uchida

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.