Neural cue reactivity during acute abstinence predicts short-term smoking relapse.

Addiction Biology
Cheyenne AllenbyCaryn Lerman

Abstract

In smokers, neural responses to smoking cues can be sensitive to acute abstinence, but the degree to which abstinence-related cue reactivity contributes to relapse is not fully understood. This study addressed this question in a sample of 75 smokers who were motivated to quit smoking. Participants underwent blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) during presentation of visual smoking cues and neutral stimuli on two occasions: once during smoking satiety and once following 24-hour abstinence (order counterbalanced). Following the imaging sessions, participants received brief smoking cessation counseling prior to a short-term (7-day) quit attempt. The primary smoking cessation outcome was biochemically confirmed 7-day relapse. The secondary smoking cessation outcome measure was total number of self-reported days of abstinence. During abstinence (vs satiety), smoking cue reactivity was significantly increased only in the anterior cingulate cortex (ACC); other regions showing a cue (vs neutral) response did not exhibit an abstinence effect in the stringent whole-brain analysis. Participants who showed greater smoking cue reactivity in the ACC during acute abstinence (compared with smoking sa...Continue Reading

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References

Nov 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J WorsleyP Neelin
Mar 1, 1986·Archives of General Psychiatry·J R Hughes, D Hatsukami
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Mar 22, 2001·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·L S CoxA G Christen
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Dec 10, 2002·Archives of General Psychiatry·Arthur L BrodyMurray E Jarvik
Mar 6, 2004·Nature Neuroscience·Stephen J WilsonJulie A Fiez
Mar 31, 2004·NeuroImage·Mark W WoolrichStephen M Smith
Nov 24, 2004·Trends in Cognitive Sciences·Matthew M BotvinickCameron S Carter
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F Joseph McClernonJed E Rose
Aug 9, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stephen J WilsonJulie A Fiez
Apr 7, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dharma McBrideAlain Dagher
Mar 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Britta HahnElliot A Stein
Aug 22, 2008·Journal of Substance Abuse Treatment·Stuart G Ferguson, Saul Shiffman
Jan 5, 2011·Archives of General Psychiatry·Christopher S CulbertsonArthur L Brody
Jan 26, 2011·The European Journal of Neuroscience·Simone Kühn, Jürgen Gallinat
Oct 26, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Karl Fagerström
Dec 31, 2011·NeuroImage·Jeffrey M EngelmannPaul M Cinciripini
Jun 20, 2012·Journal of Abnormal Psychology·Saul ShiffmanSarah Scholl
Aug 15, 2012·Experimental and Clinical Psychopharmacology·Cynthia A ConklinCarolyn A Fonte
Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A PerkinsNancy C Jao
Apr 17, 2013·Clinical Pharmacology and Therapeutics·K J BoughS Amur
May 28, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric D ClausKent E Hutchison
Aug 8, 2013·NeuroImage·Theodore D SatterthwaiteRaquel E Gur
Jan 1, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Francesco VersacePaul M Cinciripini
Jul 31, 2014·Addiction·Stephen J Wilson, Michael A Sayette
Dec 4, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James LougheadCaryn Lerman
Jan 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amy C JanesScott E Lukas
Oct 6, 2015·Addiction Biology·Kelly E CourtneyLara A Ray
Jan 26, 2016·Biological Psychiatry·Mary FalconeCaryn Lerman
Apr 19, 2016·Psychopharmacology·Rebecca L AshareJames Loughead
May 20, 2017·Psychiatry Research. Neuroimaging·Claire E WilcoxKent E Hutchison

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Citations

Jun 20, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Osama A AbulseoudElliot Stein
Jun 28, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Raoul DieterichTanja Endrass
Sep 10, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Kainan S WangAmy C Janes
Aug 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ahmet O CeceliRita Z Goldstein

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