Neural Damage in Experimental Trypanosoma brucei gambiense Infection: The Suprachiasmatic Nucleus

Frontiers in Neuroanatomy
Chiara TesorieroMarina Bentivoglio

Abstract

Trypanosoma brucei (T. b.) gambiense is the parasite subspecies responsible for most reported cases of human African trypanosomiasis (HAT) or sleeping sickness. This severe infection leads to characteristic disruption of the sleep-wake cycle, recalling attention on the circadian timing system. Most animal models of the disease have been hitherto based on infection of laboratory rodents with the T. b. brucei subspecies, which is not infectious to humans. In these animal models, functional, rather than structural, alterations of the master circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN), have been reported. Information on the SCN after infection with the human pathogenic T. b. gambiense is instead lacking. The present study was aimed at the examination of the SCN after T. b. gambiense infection of a susceptible rodent, the multimammate mouse, Mastomys natalensis, compared with T. b. brucei infection of the same host species. The animals were examined at 4 and 8 weeks post-infection, when parasites (T. b. gambiense or T. b. brucei) were detected in the brain parenchyma, indicating that the disease was in the encephalitic stage. Neuron and astrocyte changes were examined with Nissl staining, immunophenotyping an...Continue Reading

References

Dec 1, 1976·Experimental Parasitology·W J Herbert, W H Lumsden
Jun 15, 1980·The Journal of Comparative Neurology·A N Van den Pol
May 26, 1998·Journal of Neuropathology and Experimental Neurology·G B LundkvistK Kristensson
Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Jul 12, 2002·Cell and Tissue Research·Robert Y MooreRehana K Leak
Jan 18, 2003·Sleep Medicine Reviews·A BuguetM Dumas
Dec 19, 2003·Experimental Biology and Medicine·A DarsaudA Buguet
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lance J KriegsfeldRae Silver
Mar 8, 2005·Trends in Neurosciences·Michael C Antle, Rae Silver
Sep 2, 2005·Tropical Medicine & International Health : TM & IH·Philippe BüscherChantal Van Overmeir
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
Sep 7, 2006·Journal of Neuroscience Research·María Juliana LeoneDiego A Golombek
Oct 16, 2007·Journal of Neuroimmunology·Maria Palomba, Marina Bentivoglio
Aug 16, 2008·Brain Research·Andrew N Coogan, Cathy A Wyse
Aug 30, 2008·Annals of Neurology·Peter G E Kennedy
Dec 10, 2009·Progress in Neurobiology·Krister KristenssonMarina Bentivoglio
Apr 27, 2010·Trends in Cognitive Sciences·Charalambos P Kyriacou, Michael H Hastings
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luciano MarpeganChristian Beaulé
Sep 20, 2011·Brain Structure & Function·Huazheng LiangCharles Watson
Feb 22, 2012·PLoS Neglected Tropical Diseases·Alfred K NjamnshiMarina Bentivoglio
Apr 14, 2012·Chronobiology International·Paul F Seke EtetGiuseppe Bertini
Oct 17, 2012·PloS One·Emma K O'CallaghanAndrew N Coogan
Aug 1, 2013·Progress in Molecular Biology and Translational Science·Robert Y Moore
Dec 18, 2013·Journal of Neuroendocrinology·M H HastingsE S Maywood
Aug 16, 2014·Clinical Epidemiology·Jose R FrancoJean G Jannin
Feb 15, 2015·Molecular Neurobiology·Wei DuanQing Yin
Jul 5, 2017·Lancet·Philippe BüscherGerardo Priotto
Sep 29, 2017·Transactions of the Royal Society of Tropical Medicine and Hygiene·Alfred K NjamnshiPeter G E Kennedy

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Citations

Jan 9, 2019·Frontiers in Immunology·Marina BentivoglioMartin E Rottenberg
Nov 24, 2019·International Journal of Molecular Sciences·Sailen Barik
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Priscilla Carvalho CabralNicolas Cermakian

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Methods Mentioned

BETA
Confocal microscopy

Software Mentioned

ARRIVE
Image Pro Plus

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