Neural detection of complex sound sequences in the absence of consciousness

Brain : a Journal of Neurology
Athina TzovaraMarzia De Lucia

Abstract

The neural response to a violation of sequences of identical sounds is a typical example of the brain's sensitivity to auditory regularities. Previous literature interprets this effect as a pre-attentive and unconscious processing of sensory stimuli. By contrast, a violation to auditory global regularities, i.e. based on repeating groups of sounds, is typically detectable when subjects can consciously perceive them. Here, we challenge the notion that global detection implies consciousness by testing the neural response to global violations in a group of 24 patients with post-anoxic coma (three females, age range 45-87 years), treated with mild therapeutic hypothermia and sedation. By applying a decoding analysis to electroencephalographic responses to standard versus deviant sound sequences, we found above-chance decoding performance in 10 of 24 patients (Wilcoxon signed-rank test, P < 0.001), despite five of them being mildly hypothermic, sedated and unarousable. Furthermore, consistently with previous findings based on the mismatch negativity the progression of this decoding performance was informative of patients' chances of awakening (78% predictive of awakening). Our results show for the first time that detection of global...Continue Reading

References

Jul 13, 1974·Lancet·G Teasdale, B Jennett
Apr 17, 2007·Brain Research·Alexandra ListShlomo Bentin
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tristan A BekinschteinLionel Naccache
Sep 24, 2010·The New England Journal of Medicine·Michael Holzer
Apr 28, 2011·Neuron·Stanislas Dehaene, Jean-Pierre Changeux
Dec 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Catherine WacongneStanislas Dehaene
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fosco BernasconiLucas Spierer
Feb 11, 2012·Neurology·Andrea O RossettiMauro Oddo
Aug 15, 2012·Developmental Neuropsychology·Athina TzovaraMarzia De Lucia
Nov 14, 2012·Brain : a Journal of Neurology·Athina TzovaraMarzia De Lucia
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Srivas ChennuTristan A Bekinschtein
Nov 19, 2013·The New England Journal of Medicine·Niklas NielsenUNKNOWN TTM Trial Investigators
Jan 24, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lynn UhrigBéchir Jarraya
Jan 28, 2014·Critical Care Medicine·Mauro Oddo, Andrea O Rossetti
Mar 13, 2014·Frontiers in Psychology·Natacha CossyMarzia De Lucia

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Citations

Jul 4, 2015·Brain : a Journal of Neurology·Lionel NaccacheStanislas Dehaene
Mar 28, 2016·Brain : a Journal of Neurology·Lionel NaccacheStanislas Dehaene
Mar 28, 2016·Brain : a Journal of Neurology·Marzia De Lucia, Athina Tzovara
Mar 28, 2016·Brain : a Journal of Neurology·Damien GabrielThierry Moulin
Apr 25, 2015·Brain : a Journal of Neurology·Andrea PiarulliSteven Laureys
Apr 21, 2016·Nature Reviews. Neuroscience·Christof KochGiulio Tononi
Feb 26, 2016·Annals of Neurology·Athina TzovaraMarzia De Lucia
Jun 18, 2016·Frontiers in Human Neuroscience·Stefanie Blain-MoraesGeorge A Mashour
Dec 19, 2017·The European Journal of Neuroscience·Nikolaos C AggelopoulosMichael Brosch
Dec 3, 2015·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Matthew A Koenig, Peter W Kaplan
Sep 12, 2017·Annals of Neurology·Federico RaimondoJacobo D Sitt
Nov 3, 2017·Scientific Reports·Christian Pfeiffer, Marzia De Lucia
Feb 25, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D KondziellaUNKNOWN EAN Panel on Coma, Disorders of Consciousness
Dec 6, 2017·Brain : a Journal of Neurology·Lionel Naccache
Sep 27, 2018·Annals of Clinical and Translational Neurology·Christian PfeifferMarzia De Lucia
Nov 19, 2015·Frontiers in Psychology·Alana M Campbell, Deana B Davalos
May 16, 2020·Scientific Reports·Maja D FoldalTor Endestad
Sep 12, 2020·Journal of Neural Engineering·Elizabeth L JohnsonRobert T Knight
Feb 2, 2021·Frontiers in Human Neuroscience·Rony HirschhornLiad Mudrik
Jun 27, 2021·Trends in Cognitive Sciences·Cole DembskiMichael Pitts
Sep 13, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A ComanducciM Massimini
Sep 3, 2021·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Estelle Pruvost-RobieuxMartine Gavaret

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