Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells

Biochemical and Biophysical Research Communications
K YoshikawaK Maruyama

Abstract

Neural differentiation of the embryonal carcinoma P19 cell line markedly increased the abundance of mRNA encoding Alzheimer amyloid beta/A4-protein precursor (APP). In P19 cells treated with retinoic acid, the abundance of mRNA encoding APP695, which lacks the protease inhibitor domain, reached a maximum on days 2-4 and decreased thereafter, whereas the abundances of mRNAs encoding APP751 and APP770, both possessing the protease inhibitor domain, slowly increased to reach higher levels than APP695 mRNA at later stages of neural differentiation. The induction of APP695 mRNA was consistent with the appearance of neurons in the P19 cultures. A high abundance of APP695 mRNA was also detected in mouse brain at a stage of the period of neuroblast formation. Thus, neural differentiation of P19 cells may present a suitable model for studying the regulation of APP gene expression during early differentiation of brain cells in vivo.

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Citations

Mar 1, 1994·Metabolic Brain Disease·A LeBlanc
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·M A MenaJ G de Yebenes
Mar 18, 1991·Brain Research. Developmental Brain Research·T AizawaK Yoshikawa
Aug 21, 1992·Brain Research. Developmental Brain Research·T AizawaK Yoshikawa
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May 10, 2000·Neuroscience Research·K Yoshikawa
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Dec 31, 1993·Brain Research·S DevR B Edwards
Jul 15, 1991·Biochemical and Biophysical Research Communications·K MaruyamaK Yoshikawa
Aug 3, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kazuaki Yoshikawa

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