Neural differentiation of mesenchymal stem cells influences chemotactic responses to HGF

Journal of Cellular Physiology
Bing ZhengHuanxiang Zhang

Abstract

Recently, mesenchymal stem cells (MSCs) have been extensively used for cell-based therapies in neuronal degenerative disease. Although much effort has been devoted to the delineation of factors involved in the migration of MSCs, the relationship between the chemotactic responses and the differentiation status of these cells remains elusive. Here, we report that MSCs in varying neural differentiation states display different chemotactic responses to hepatocyte growth factor (HGF): first, the number of chemotaxing MSCs and the optimal concentrations of HGF that induced the peak migration varied greatly; second, time-lapse video analysis showed that MSCs in certain differentiation state migrated more efficiently toward HGF; third, the phosphorylation levels of Akt, ERK1/2, SAPK/JNK, and p38MAPK were closely related to the differentiation levels of MSCs subjected to HGF; and finally, although inhibition of ERK1/2 signaling significantly attenuated HGF-stimulated transfilter migration of both undifferentiated and differentiating MSCs, abolishment of PI3K/Akt, p38MAPK, or SAPK/JNK signaling only decreased the number of migrated cells in certain differentiation state(s). Blocking of PI3K/Akt or MAPK signaling impaired the migration ef...Continue Reading

References

Mar 11, 1999·Current Opinion in Neurobiology·S Temple, A Alvarez-Buylla
Apr 2, 1999·Science·M F PittengerD R Marshak
Jun 4, 1999·Trends in Cell Biology·J M SerradorF Sánchez-Madrid
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·G C KopenD G Phinney
Jul 6, 2000·Nature·S S MagaviJ D Macklis
Aug 10, 2000·Journal of Neuroscience Research·D WoodburyI B Black
May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·P StephensD W Thomas
Jan 26, 2002·Molecular and Cellular Biology·Markus MüllerCarola Ponzetto
Apr 3, 2002·The Journal of Clinical Investigation·Paolo M Comoglio, Livio Trusolino
Sep 3, 2002·Journal of Neuroscience Research·Juan R Sanchez-Ramos
Oct 25, 2002·Journal of Cellular Biochemistry·Jörg FiedlerRolf E Brenner
Mar 18, 2003·Transplantation·Gordon D WuDonald V Cramer
Sep 17, 2004·Journal of Cell Science·Cai HuangMichael D Schaller
Oct 20, 2004·Journal of Cellular and Molecular Medicine·Stefania CortiG P Comi
Apr 2, 2005·Nature Cell Biology·Anna Huttenlocher
Jul 12, 2005·Biochemical and Biophysical Research Communications·Jörg FiedlerRolf E Brenner
Dec 20, 2005·The Journal of Biological Chemistry·Joseph SegarraFabienne Lamballe
Aug 16, 2006·Neuro-degenerative Diseases·Eva Syková, Pavla Jendelová
Oct 10, 2006·European Journal of Oral Sciences·Eleni GagariPetros D Damoulis
Dec 30, 2006·Stroke; a Journal of Cerebral Circulation·Woei-Cherng ShyuHung Li
Jan 19, 2008·Trends in Neurosciences·Duncan MortimerGeoffrey J Goodhill
May 9, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yasunori Mishima, Martin Lotz
Jun 5, 2008·Cell Transplantation·Tasneem ZahirMolly Shoichet
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Donatella GarzottoSilvia De Marchis
Mar 24, 2009·Journal of Neurosurgery·Matthew T HartingCharles S Cox

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Citations

Jul 19, 2013·Stem Cells International·Julia van de KampSabine Neuss
Nov 6, 2015·Journal of Cellular Biochemistry·Aisi ZhuHuanxiang Zhang
Mar 31, 2015·Journal of Cellular Physiology·Huihui WangHuanxiang Zhang
Jan 13, 2015·Experimental and Therapeutic Medicine·Wen ZengMeng Mao
Mar 24, 2018·Photomedicine and Laser Surgery·Sajan GeorgeHeidi Abrahamse
Jul 31, 2019·Cells·Xiaorong FuAnd Guanbin Song
Apr 21, 2017·American Journal of Physiology. Cell Physiology·Xianyang LiHuanxiang Zhang
Jun 21, 2017·Stem Cells International·Jing Qu, Huanxiang Zhang
Dec 8, 2019·International Journal of Molecular Sciences·Kentaro YamaneAkihiro Matsukawa
Dec 24, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Se-Ra ParkHwa-Yong Lee
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Claudia DesoleTiziana Crepaldi
Jun 28, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Se-Ra ParkIn-Sun Hong

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