Neural electrical activity and neural network growth

Neural Networks : the Official Journal of the International Neural Network Society
F M Gafarov

Abstract

The development of central and peripheral neural system depends in part on the emergence of the correct functional connectivity in its input and output pathways. Now it is generally accepted that molecular factors guide neurons to establish a primary scaffold that undergoes activity-dependent refinement for building a fully functional circuit. However, a number of experimental results obtained recently shows that the neuronal electrical activity plays an important role in the establishing of initial interneuronal connections. Nevertheless, these processes are rather difficult to study experimentally, due to the absence of theoretical description and quantitative parameters for estimation of the neuronal activity influence on growth in neural networks. In this work we propose a general framework for a theoretical description of the activity-dependent neural network growth. The theoretical description incorporates a closed-loop growth model in which the neural activity can affect neurite outgrowth, which in turn can affect neural activity. We carried out the detailed quantitative analysis of spatiotemporal activity patterns and studied the relationship between individual cells and the network as a whole to explore the relationshi...Continue Reading

Citations

Feb 6, 2020·Cognitive Neurodynamics·Zuolei Wang, Xuerong Shi
Dec 13, 2019·Neural Networks : the Official Journal of the International Neural Network Society·Julio A Peraza-GoicoleaRoberto Mulet
Nov 14, 2020·International Journal of Molecular Sciences·Malwina LisekTomasz Boczek
Sep 3, 2021·Bioelectricity·Jarno M A TanskanenJari A K Hyttinen

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