Jul 17, 2016

Neural, electrophysiological and anatomical basis of brain-network variability and its characteristic changes in mental disorders

Brain : a Journal of Neurology
Jie ZhangJianfeng Feng

Abstract

SEE MATTAR ET AL DOI101093/AWW151 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Functional brain networks demonstrate significant temporal variability and dynamic reconfiguration even in the resting state. Currently, most studies investigate temporal variability of brain networks at the scale of single (micro) or whole-brain (macro) connectivity. However, the mechanism underlying time-varying properties remains unclear, as the coupling between brain network variability and neural activity is not readily apparent when analysed at either micro or macroscales. We propose an intermediate (meso) scale analysis and characterize temporal variability of the functional architecture associated with a particular region. This yields a topography of variability that reflects the whole-brain and, most importantly, creates an analytical framework to establish the fundamental relationship between variability of regional functional architecture and its neural activity or structural connectivity. We find that temporal variability reflects the dynamical reconfiguration of a brain region into distinct functional modules at different times and may be indicative of brain flexibility and adaptability. Primary and unimodal sensory-motor cortices demons...Continue Reading

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  • Citations27

Mentioned in this Paper

Research in General
Study
Limbic System
Brain Diseases
Electroencephalography
Default
Schizophrenia
Functional Neuroimaging
Diffusion Magnetic Resonance Imaging
Neuroma

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