Neural Function Before and After Mindfulness-Based Cognitive Therapy in Anxious Adolescents at Risk for Developing Bipolar Disorder

Journal of Child and Adolescent Psychopharmacology
Jeffrey R StrawnMelissa P DelBello

Abstract

We sought to evaluate the neurophysiology of mindfulness-based cognitive therapy for children (MBCT-C) in youth with generalized, social, and/or separation anxiety disorder who were at risk for developing bipolar disorder. Nine youth (mean age: 13 ± 2 years) with a generalized, social, and/or separation anxiety disorder and a parent with bipolar disorder completed functional magnetic resonance imaging (fMRI) while performing a continuous processing task with emotional and neutral distractors (CPT-END) prior to and following 12 weeks of MBCT-C. MBCT-C was associated with increases in activation of the bilateral insula, lentiform nucleus, and thalamus, as well as the left anterior cingulate while viewing emotional stimuli during the CPT-END, and decreases in anxiety were correlated with change in activation in the bilateral insula and anterior cingulate during the viewing of emotional stimuli (p < 0.05, uncorrected; p < 0.005 corrected; cluster size, 37 voxels). MBCT-C treatment in anxious youth with a familial history of bipolar disorder is associated with increased activation of brain structures that subserve interoception and the processing of internal stimuli-functions that are ostensibly improved by this treatment.

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Citations

Jun 9, 2019·Brain Sciences·Michael EggartBruno Müller-Oerlinghausen
Jun 6, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jeffrey R StrawnJohn T Walkup
Jul 8, 2020·Healthcare·María Del Mar Molero JuradoJosé Jesús Gázquez Linares
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Mar 6, 2018·Current Treatment Options in Psychiatry·Isheeta Zalpuri, Manpreet K Singh
Feb 5, 2021·Frontiers in Human Neuroscience·Olga Tymofiyeva, Robert Gaschler

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pharmacotherapy

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AFNI

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