Neural influence on slow muscle properties: inactivity with and without cross-reinnervation

Muscle & Nerve
R R RoyV R Edgerton

Abstract

The effects of altering (cross-reinnervation, CR) and/or eliminating (spinal isolation, SI) the activation-dependent neural input to the cat soleus for 8 months on its mechanical and biochemical properties were determined. The percent fast fibers was 0, 27, 38, and 54% for normal control (NC), NC-CR, SI, and SI-CR cats. Calcium-activated whole muscle myofibrillar adenosine triphosphatase activity was higher in SI-CR and NC cats. Isometric twitch speed properties and frequency of stimulation:tension response were faster in all experimental groups compared to NC. Maximum twitch and tetanic (Po) force, physiological cross-sectional area (PCSA), and specific tension (Po/PCSA) were unaffected in NC-CR cats, but reduced in SI and SI-CR cats. The soleus was more fatigable in SI-CR compared to NC cats. Alpha-glycerophosphate dehydrogenase activity was higher in all experimental groups compared to NC. All eight parameters reflecting the type of muscle were shifted toward those observed in a "faster" muscle in SI-CR vs. SI cats. These data suggest that electrically silent motoneurons can influence type-related skeletal muscle properties.

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Citations

Mar 18, 2008·The Journal of Experimental Biology·Roland R RoyV Reggie Edgerton
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hyung ChoiBryan C Rourke
Sep 15, 2010·The Journal of General Physiology·Mariana CasasEnrique Jaimovich
Aug 13, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Megan M NowellBryan C Rourke
Nov 1, 2002·American Journal of Physical Medicine & Rehabilitation·V Reggie EdgertonRyan J Monti
Sep 1, 2017·Muscle & Nerve·Stanley Salmons
Sep 5, 2002·Muscle & Nerve·Roland R RoyV Reggie Edgerton
May 25, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kristina WeimerJoseph X DiMario
Sep 5, 2002·Muscle & Nerve·Roland R RoyV R Edgerton
Aug 10, 2006·European Journal of Applied Physiology·Menotti Midrio
Sep 5, 2002·Muscle & Nerve·Hui ZhongV Reggie Edgerton
Jun 22, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A Jakubiec-PukaA Matusiak
May 2, 2006·Progress in Neurobiology·Jonathan R Wolpaw, Jonathan S Carp

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