Neural map formation and sensory coding in the vomeronasal system

Cellular and Molecular Life Sciences : CMLS
Alexandra C Brignall, Jean-François Cloutier

Abstract

Sensory systems enable us to encode a clear representation of our environment in the nervous system by spatially organizing sensory stimuli being received. The organization of neural circuitry to form a map of sensory activation is critical for the interpretation of these sensory stimuli. In rodents, social communication relies strongly on the detection of chemosignals by the vomeronasal system, which regulates a wide array of behaviours, including mate recognition, reproduction, and aggression. The binding of these chemosignals to receptors on vomeronasal sensory neurons leads to activation of second-order neurons within glomeruli of the accessory olfactory bulb. Here, vomeronasal receptor activation by a stimulus is organized into maps of glomerular activation that represent phenotypic qualities of the stimuli detected. Genetic, electrophysiological and imaging studies have shed light on the principles underlying cell connectivity and sensory map formation in the vomeronasal system, and have revealed important differences in sensory coding between the vomeronasal and main olfactory system. In this review, we summarize the key factors and mechanisms that dictate circuit formation and sensory coding logic in the vomeronasal sys...Continue Reading

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Citations

Sep 27, 2018·Chemical Senses·Julia MohrhardtMarc Spehr
Oct 22, 2019·Genes, Brain, and Behavior·James A Cherry, Michael J Baum
Aug 18, 2017·Brain Structure & Function·Alexandra C BrignallJean-François Cloutier
Aug 11, 2020·BMC Evolutionary Biology·Caitlin H MillerMichael J Sheehan
May 22, 2018·Frontiers in Molecular Neuroscience·Paige Whyte-FagundesGeorg Zoidl
Apr 20, 2021·Cellular and Molecular Life Sciences : CMLS·Raghu Ram Katreddi, Paolo E Forni
Oct 3, 2021·Scientific Reports·Sydney FearnleyJean-François Cloutier
Jul 14, 2021·Physiological Reviews·Ivan ManziniCorrado Di Natale

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