PMID: 15374260Jan 1, 1995Paper

Neural mechanisms in hypertension and the elderly

Archives of Gerontology and Geriatrics
G GrassiG Mancia

Abstract

Experimental animal studies carried out over the past 40 years have unequivocally shown that neurogenic mechanisms are involved in the pathogenesis of hypertension. The results of these studies also suggest that neural factors are important not only in the development but also in the maintenance of the high blood pressure condition. Whether this is the case also for human hypertension has been matter of debate for several decades. However, recent studies in man by employing sophisticated techniques for assessing sympathetic tone, i.e. the norepinephrine radiolabelled technique and microneurographic recording of sympathetic nerve traffic, support the hypothesis that alterations in sympathetic modulation of the cardiovascular system take place in hypertension and may have a pathogenetic relevance in age-related blood pressure increase.

References

Aug 1, 1978·Circulation Research·G ManciaA Zanchetti
May 27, 1976·Nature·M G ZieglerI J Kopin
Jan 1, 1988·Annual Review of Physiology·B G Wallin, J Fagius
Jan 1, 1969·Circulation·J D BristowH S Smyth
Dec 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·G ManciaA Daffonchio
Aug 19, 2011·Journal of Nutrition in Gerontology and Geriatrics·Arnab Ghosh, Sanjib Kumar Bala

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Citations

Sep 6, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J Kevin Shoemaker

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