Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward

Journal of Child and Adolescent Psychopharmacology
Denis G SukhodolskyKevin A Pelphrey

Abstract

We present the rationale and design of a randomized controlled trial of cognitive-behavioral therapy (CBT) for aggression in children and adolescents, which is conducted in response to the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) approach initiative. Specifically, the study is focused on the brain-behavior associations within the RDoC construct of frustrative non-reward. On the behavioral level, this construct is defined by reactions elicited in response to withdrawal or prevention of reward, most notably reactive aggression. This study is designed to test the functional magnetic resonance (fMRI) and electrophysiological (EEG) correlates of aggression and its reduction after CBT. Eighty children and adolescents with high levels of aggression across multiple traditional diagnostic categories, ages 8-16, will be randomly assigned to receive 12 sessions of CBT or 12 sessions of supportive psychotherapy. Clinical outcomes will be measured by the ratings of aggressive behavior collected at baseline, midpoint, and endpoint evaluations, and by the Improvement Score of the Clinical Global Impressions Scale assigned by an independent evaluator (blinded rater). Subjects will also perform a frustration-in...Continue Reading

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Citations

Jan 25, 2017·Journal of Neurodevelopmental Disorders·Y J Daniel YangPamela Ventola
May 10, 2017·Annual Review of Clinical Psychology·Melissa A BrotmanEllen Leibenluft
Sep 21, 2018·Neurology India·Sunil Pradhan, Robin Bansal
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May 7, 2020·Clinical Child Psychology and Psychiatry·Olivia J DerellaOliver G Johnston
Oct 31, 2017·Clinical Case Studies·Megan E TudorDenis G Sukhodolsky
Mar 15, 2018·Journal of Autism and Developmental Disorders·Alan S LewisDenis G Sukhodolsky
Oct 16, 2018·Current Treatment Options in Psychiatry·Katharina KircanskiMelissa A Brotman
Dec 1, 2020·Developmental Cognitive Neuroscience·Karim IbrahimDenis G Sukhodolsky
May 14, 2020·Clinical Psychology Review·Laura Castillo-EitoRichard Rowe
Jun 1, 2021·Child and Adolescent Psychiatric Clinics of North America·James G WaxmonskyDaniel A Waschbusch
Dec 2, 2021·Social Cognitive and Affective Neuroscience·Denis G SukhodolskyMichelle Hampson

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