Neural mechanisms of the testosterone-aggression relation: the role of orbitofrontal cortex

Journal of Cognitive Neuroscience
Pranjal H Mehta, Jennifer Beer

Abstract

Testosterone plays a role in aggressive behavior, but the mechanisms remain unclear. The present study tested the hypothesis that testosterone influences aggression through the OFC, a region implicated in self-regulation and impulse control. In a decision-making paradigm in which people chose between aggression and monetary reward (the ultimatum game), testosterone was associated with increased aggression following social provocation (rejecting unfair offers). The effect of testosterone on aggression was explained by reduced activity in the medial OFC. The findings suggest that testosterone increases the propensity toward aggression because of reduced activation of the neural circuitry of impulse control and self-regulation.

References

Jan 1, 1991·Psychoneuroendocrinology·R M Sapolsky
Dec 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·E T RollsJ McGrath
Dec 15, 1995·Annals of the New York Academy of Sciences·D M TuckerK H Pribram
Jan 1, 1997·Behavioural Brain Research·E P BlessJ B Mitchell
Mar 24, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·X LiuE D London
Apr 16, 1998·Psychiatry Research·E G StålenheimL Wide
Mar 31, 1999·The Behavioral and Brain Sciences·A Mazur, A Booth
Jun 3, 1999·Acta Psychiatrica Scandinavica·P RäsänenJ Tiihonen
Jan 8, 2000·Physiology & Behavior·J L Ruiz-de-la-torre, X Manteca
Mar 24, 2000·Cerebral Cortex·A BecharaA R Damasio
Jun 7, 2000·Chronobiology International·Y Touitou, E Haus
Jan 3, 2001·Nature Neuroscience·J O'DohertyC Andrews
Jun 8, 2001·Trends in Cognitive Sciences·S RahmanT Robbins
Jul 28, 2001·Biological Psychology·V J Grant, J T France
Dec 26, 2001·Annual Review of Psychology·Craig A Anderson, Brad J Bushman
Aug 6, 2002·Science·Avshalom CaspiRichie Poulton
Jun 14, 2003·Science·Alan G SanfeyJonathan D Cohen
Oct 17, 2003·Journal of Personality and Social Psychology·Jennifer S BeerRobert T Knight
Apr 6, 2004·Lancet·Ian Everall, Igor Grant
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
May 26, 2004·Psychopharmacology·Antonia S NewLarry J Siever
Jun 5, 2004·Psychoneuroendocrinology·Jack van HonkHans Koppeschaar
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Daryl B O'ConnorFrederick C W Wu
Nov 20, 2004·Nature Reviews. Neuroscience·Nora D Volkow, Ting-Kai Li
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Kristopher J Preacher, Andrew F Hayes
Jan 25, 2005·Hormones and Behavior·Matthew L NewmanRobert A Josephs
Sep 2, 2005·Nature Reviews. Neuroscience·Morten L Kringelbach
Dec 27, 2005·Frontiers in Neuroendocrinology·Brian C TrainorCatherine A Marler
Feb 18, 2006·Neuroscience and Biobehavioral Reviews·John Archer
Feb 21, 2006·Experimental Brain Research·Mascha van 't WoutAndré Aleman
Jun 21, 2006·Journal of Personality and Social Psychology·Robert A JosephsPranjal H Mehta
Jul 15, 2006·Journal of Cognitive Neuroscience·Jennifer S BeerRobert T Knight
Aug 5, 2006·Science·Benedetto De MartinoRaymond J Dolan
Aug 25, 2006·Hormones and Behavior·Pranjal H Mehta, Robert A Josephs

❮ Previous
Next ❯

Citations

Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hidehiko TakahashiTetsuya Suhara
Jul 19, 2013·Journal of Cognitive Neuroscience·Jiska S PeperEveline A Crone
Mar 26, 2013·PLoS Biology·Bevil R Conway, Alexander Rehding
Oct 17, 2012·PloS One·Matthias WibralArmin Falk
Jan 15, 2014·PloS One·P Cédric M P KoolschijnEveline A Crone
Nov 16, 2013·Psychiatry Research·Or DuekOra Kofman
Sep 9, 2010·Annual Review of Psychology·James K Rilling, Alan G Sanfey
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Roscoe Stanyon, Francesca Bigoni
Apr 5, 2013·Behavioral Ecology : Official Journal of the International Society for Behavioral Ecology·Isabel M L ScottIan S Penton-Voak
Sep 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Isabel M ScottIan S Penton-Voak
Jun 7, 2011·Psychoneuroendocrinology·Jiska S PeperJack van Honk
May 5, 2011·Neuroscience·G A van WingenG Fernández
Mar 15, 2016·Frontiers in Neuroscience·Eleni KopsidaMartin Ingvar
Sep 21, 2010·Current Opinion in Neurobiology·Joan Y Chiao
Sep 8, 2010·Hormones and Behavior·Pranjal H Mehta, Robert A Josephs
Jul 24, 2010·Journal of Personality·Hani D Freeman, Jennifer S Beer
Apr 3, 2015·Aggressive Behavior·Shawn N GenioleCheryl M McCormick
Oct 11, 2011·Developmental Cognitive Neuroscience·Ilanit GordonJames F Leckman
Nov 5, 2015·International Journal of Adolescent Medicine and Health·Timothy R Rice, Leo Sher
Feb 15, 2015·Social Cognitive and Affective Neuroscience·Franziska DambacherAlexander T Sack
Apr 13, 2015·Brain Imaging and Behavior·Erin McGladeDeborah Yurgelun-Todd
Oct 3, 2014·Developmental Psychobiology·Leonardo BobadillaElizabeth A Shirtcliff
Jul 1, 2015·Frontiers in Neuroscience·Luise Reimers, Esther K Diekhof
May 15, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Peter HöferSiegfried Kasper
Feb 2, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kathryn G Wallin, Ruth I Wood
Mar 31, 2015·Psychoneuroendocrinology·Pranjal H MehtaJustin M Carré
Mar 19, 2014·Physiology & Behavior·Keith M WelkerJustin M Carré
Apr 16, 2014·Hormones and Behavior·Samuele ZilioliNeil V Watson
Sep 25, 2016·Research in Veterinary Science·Efrat KoreshLee Koren
Nov 24, 2012·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·Thomas F Denson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.