Neural mechanisms supporting the relationship between dispositional mindfulness and pain

Pain
Fadel ZeidanRobert C Coghill

Abstract

Interindividual differences in pain sensitivity vary as a function of interactions between sensory, cognitive-affective, and dispositional factors. Trait mindfulness, characterized as the innate capacity to nonreactively sustain attention to the present moment, is a psychological construct that is associated with lower clinical pain outcomes. Yet, the neural mechanisms supporting dispositional mindfulness are unknown. In an exploratory data analysis obtained during a study comparing mindfulness to placebo analgesia, we sought to determine whether dispositional mindfulness is associated with lower pain sensitivity. We also aimed to identify the brain mechanisms supporting the postulated inverse relationship between trait mindfulness and pain in response to noxious stimulation. We hypothesized that trait mindfulness would be associated with lower pain and greater deactivation of the default mode network. Seventy-six meditation-naive and healthy volunteers completed the Freiburg Mindfulness Inventory and were administered innocuous (35°C) and noxious stimulation (49°C) during perfusion-based functional magnetic resonance imaging. Higher Freiburg Mindfulness Inventory ratings were associated with lower pain intensity (P = 0.005) an...Continue Reading

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Citations

Feb 13, 2020·Frontiers in Immunology·Gilson Gonçalves Dos SantosMaripat Corr
Oct 29, 2020·Pain Management·Paul GlareKarin Aubrey
Dec 29, 2020·CNS Neuroscience & Therapeutics·Feifei ZhangQiyong Gong
Jan 30, 2021·Explore : the Journal of Science and Healing·Kimia ZarabianMikhail Kogan
Feb 23, 2021·Frontiers in Human Neuroscience·Semra A AyturDonald A Robin
Apr 20, 2021·Frontiers in Psychology·Sabina BaltruschatAndrés Catena

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