Neural metabolic activity in idiopathic tinnitus patients after repetitive transcranial magnetic stimulation

World Journal of Clinical Cases
Ying KanJi-Gang Yang

Abstract

The central mechanism of idiopathic tinnitus is related to hyperactivity of cortical and subcortical auditory and non-auditory areas. Repetitive transcranial magnetic stimulation (rTMS) is a well-tolerated, non-invasive potential treatment option for tinnitus. To investigate the changes of neural metabolic activity after rTMS in chronic idiopathic tinnitus (IT) patients. Eleven patients underwent rTMS (1 Hz, 90% motor threshold, 1000 stimuli/day for consecutive 10 d) on the left temporoparietal region cortex. Tinnitus handicap inventory (THI) and visual analogue score (VAS) were assessed at baseline and posttreatment. All patients underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography to evaluate the neural metabolic activity. Data were preprocessed using statistical parametric mapping and Gretna software to extract the regions of interest (ROIs). The correlation between brain areas involved and THI scores was analyzed. Baseline and posttreatment parameters showed no significant difference regarding THI score (t = 1.019, P = 0.342 > 0.05) and VAS (t = 0.00, P = 1.0 > 0.05). Regions with the highest FDG uptake were the right inferior temporal gyrus (ITG), right parahippocampa gyrus (PHG), right hippocampus, rectus g...Continue Reading

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Citations

Mar 18, 2021·The Journal of International Medical Research·Lu YinJuntao Yan
Nov 28, 2021·Journal of Clinical Medicine·Alexa J DentonAdrien A Eshraghi

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Methods Mentioned

BETA
imaging techniques
imaging technique

Software Mentioned

Gretna Graph - theoretical Network Analysis Toolkit
SPSS
Matlab
Statistical Parametric Mapping ( SPM12

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