Neural Modulation of the Primary Auditory Cortex by Intracortical Microstimulation with a Bio-Inspired Electronic System

Bioengineering
Maria Giovanna BiancoAntonino S Fiorillo

Abstract

Nowadays, the majority of the progress in the development of implantable neuroprostheses has been achieved by improving the knowledge of brain functions so as to restore sensorial impairments. Intracortical microstimulation (ICMS) is a widely used technique to investigate site-specific cortical responses to electrical stimuli. Herein, we investigated the neural modulation induced in the primary auditory cortex (A1) by an acousto-electric transduction of ultrasonic signals using a bio-inspired intracortical microstimulator. The developed electronic system emulates the transduction of ultrasound signals in the cochlea, providing bio-inspired electrical stimuli. Firstly, we identified the receptive fields in the primary auditory cortex devoted to encoding ultrasonic waves at different frequencies, mapping each area with neurophysiological patterns. Subsequently, the activity elicited by bio-inspired ICMS in the previously identified areas, bypassing the sense organ, was investigated. The observed evoked response by microstimulation resulted as highly specific to the stimuli, and the spatiotemporal dynamics of neural oscillatory activity in the alpha, beta, and gamma waves were related to the stimuli preferred by the neurons at the...Continue Reading

References

Feb 4, 1999·Biophysical Journal·P P Mitra, B Pesaran
Jun 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·C HaenschelJ Gruzelier
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Gao, N Suga
Oct 22, 2002·The Journal of Comparative Neurology·Neot N DoronMalcolm N Semple
Mar 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·V HokB Poucet
Aug 5, 2006·Brain Research Reviews·Wolfgang KlimeschSimon Hanslmayr
Jan 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Etienne de Villers-SidaniMichael M Merzenich
Nov 13, 2007·Psychophysiology·L Elliot HongAnn Summerfelt
Nov 10, 2010·The European Journal of Neuroscience·Paulo Vianney-RodriguesJohn P Welsh
Jan 14, 2011·The European Journal of Neuroscience·Chris ScholesChristian J Sumner
Jan 22, 2011·Computational Intelligence and Neuroscience·Robert OostenveldJan-Mathijs Schoffelen
Sep 14, 2011·Behavioural Brain Research·Ashwini J ParsanaThomas H Brown
Oct 7, 2011·Nature·Joseph E O'DohertyMiguel A L Nicolelis
Feb 7, 2012·Progress in Neurobiology·Mark H HistedJohn H R Maunsell
Nov 13, 2012·Trends in Cognitive Sciences·Wolfgang Klimesch
Jan 18, 2013·Journal of Neurophysiology·Isaac M CarruthersMaria N Geffen
Jan 24, 2013·Nature Communications·Federico De MartinoElia Formisano
Feb 5, 2013·Current Opinion in Neurobiology·Stefan M Brudzynski
May 1, 2013·Frontiers in Physiology·Lasse JakobsenAnnemarie Surlykke
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gregg A TabotSliman J Bensmaia
Jan 28, 2014·Current Biology : CB·Randolph F HelfrichChristoph S Herrmann
Jan 24, 2015·Hearing Research·Hubert H Lim, Thomas Lenarz
Apr 7, 2015·Current Biology : CB·Hiroaki Norimoto, Yuji Ikegaya
Nov 13, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takako FujiokaLaurel J Trainor
Feb 26, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Konstantin HartmannMiguel A L Nicolelis
Apr 12, 2016·Current Protocols in Neuroscience·Markus WöhrRainer K W Schwarting
Jun 10, 2016·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Julio C HechavarríaManfred Kössl
Sep 23, 2016·Critical Reviews in Biomedical Engineering·Dayo O AdewoleD Kacy Cullen
Mar 10, 2017·Physiological Reviews·Mikhail A Lebedev, Miguel A L Nicolelis
Feb 13, 2018·Biomedical Engineering Online·Diego CaleroJúlio A Cordioli
Dec 12, 2018·Applied Bionics and Biomechanics·Gerald E Loeb

❮ Previous
Next ❯

Citations

Sep 10, 2020·Sensors·Salvatore A PullanoAntonino S Fiorillo

❮ Previous
Next ❯

Methods Mentioned

BETA
cochlear implants
PCA

Software Mentioned

OpenSorter
OpenEx
ARRIVE
R
MATLAB
Fieldtrip Toolbox

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved