Neural network correlates of high-altitude adaptive genetic variants in Tibetans: A pilot, exploratory study.

Human Brain Mapping
Zhiyue GuoJinhui Wang

Abstract

Although substantial progress has been made in the identification of genetic substrates underlying physiology, neuropsychology, and brain organization, the genotype-phenotype associations remain largely unknown in the context of high-altitude (HA) adaptation. Here, we related HA adaptive genetic variants in three gene loci (EGLN1, EPAS1, and PPARA) to interindividual variance in a set of physiological characteristics, neuropsychological tests, and topological attributes of large-scale structural and functional brain networks in 135 indigenous Tibetan highlanders. Analyses of individual HA adaptive single-nucleotide polymorphisms (SNPs) revealed that specific SNPs selectively modulated physiological characteristics (erythrocyte level, ratio between forced expiratory volume in the first second to forced vital capacity, arterial oxygen saturation, and heart rate) and structural network centrality (the left anterior orbital gyrus) with no effects on neuropsychology or functional brain networks. Further analyses of genetic adaptive scores, which summarized the overall degree of genetic adaptation to HA, revealed significant correlations only with structural brain networks with respect to local interconnectivity of the whole networks...Continue Reading

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Citations

Oct 29, 2020·The Clinical Respiratory Journal·Alejandro Talaminos-BarrosoJavier Reina-Tosina

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Methods Mentioned

BETA
genotyping

Software Mentioned

SpectroDesigner
GRETNA
PANDA
SpectroTyper
Sequenom

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