Neural Network Reconfigurations: Changes of the Respiratory Network by Hypoxia as an Example

Advances in Experimental Medicine and Biology
Fernando Peña-Ortega

Abstract

Neural networks, including the respiratory network, can undergo a reconfiguration process by just changing the number, the connectivity or the activity of their elements. Those elements can be either brain regions or neurons, which constitute the building blocks of macrocircuits and microcircuits, respectively. The reconfiguration processes can also involve changes in the number of connections and/or the strength between the elements of the network. These changes allow neural networks to acquire different topologies to perform a variety of functions or change their responses as a consequence of physiological or pathological conditions. Thus, neural networks are not hardwired entities, but they constitute flexible circuits that can be constantly reconfigured in response to a variety of stimuli. Here, we are going to review several examples of these processes with special emphasis on the reconfiguration of the respiratory rhythm generator in response to different patterns of hypoxia, which can lead to changes in respiratory patterns or lasting changes in frequency and/or amplitude.

Citations

May 10, 2018·The Journal of Physiology·Jan Marino RamirezIbis M Agosto-Marlin
Mar 29, 2019·Proceedings of the National Academy of Sciences of the United States of America·Nathan A BaertschJan-Marino Ramirez
Jan 28, 2021·Journal of Neurophysiology·Josué de Jesús Juárez-VidalesFernando Peña-Ortega

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