Neural networks of several novel neuropeptides involved in feeding regulation

Nutrition
Seiji ShiodaHaruaki Kageyama

Abstract

Novel neuropeptides acting as G-protein-coupled receptor (GPCR) ligands are known to be localized in the brain and play a range of physiologic functions, one of which is feeding regulation. We describe the distribution and localization of these recently identified GPCR ligands and review their involvement in neuronal networks, particularly in feeding regulation. This review addresses aspects of some novel GPCR ligands, including feeding-regulating neuropeptides such as orexin, ghrelin, and galanin-like peptide and other known neuropeptides such as neuropeptide Y and pro-opiomelanocortin. These neuropeptides have been studied by our research group and others, particularly with regard to interactions in the hypothalamus of neurons containing these neuropeptides. In the hypothalamus, cross-talk among such neurons plays a key role in determining feeding states and feeding behavior. We describe some structural and functional characteristics of these neuropeptides and summarize the known interactions between the different kinds of feeding-regulating neurons and leptin-targeting neurons in the hypothalamus. Moreover, we present a new strategy for analyzing neural circuits involving these feeding-regulating GPCR ligands in the brain, w...Continue Reading

References

May 13, 1999·Neuroscience Letters·H FunahashiS Shioda
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Jul 20, 2002·The Journal of Biological Chemistry·Yukio ShimomuraMasahiko Fujino
Dec 4, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J-L GuanS Shioda
Mar 18, 2003·Endocrinology·Koji ToshinaiMasamitsu Nakazato
Apr 4, 2003·Neuroscience Letters·Fumiko TakenoyaSeiji Shioda
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Sep 10, 2003·Endocrinology·Muhtashan S MondalMasamitsu Nakazato
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May 16, 2006·Brain Research·Yoji KitamuraTakeshi Sakurai

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Citations

Oct 9, 2013·General and Comparative Endocrinology·Yanling GongShengli Gao
Mar 29, 2014·BMC Bioinformatics·Tung T NguyenIoannis P Androulakis
Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers
Oct 20, 2012·Expert Opinion on Biological Therapy·Josep M Argilés, Britta Stemmler
Jan 31, 2012·Early Human Development·Francesco SavinoLeandra Silvestro
Jan 19, 2010·Nutrition·Carine De VrieseChristine Delporte
Sep 22, 2009·European Journal of Pharmacology·Toshinori AoyagiAkito Tanoue
Dec 4, 2010·The FEBS Journal·Kanako ShibaSeiji Shioda
Jul 2, 2010·British Journal of Pharmacology·Linda K VaughnCecilia J Hillard
Aug 30, 2008·Nutrition·Michael M MeguidFrank A Middleton
Jul 20, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Satoshi HirakoSeiji Shioda

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