Neural networks to identify glaucoma with structural and functional measurements

American Journal of Ophthalmology
L BrigattiJoseph Caprioli

Abstract

Neural networks can recognize patterns and classify complex variables. We assessed the ability of neural networks to discriminate between normal and glaucomatous eyes by using structural and functional measurements. Several neural network algorithms were tested with a database of 185 eyes of patients with early glaucomatous visual field loss (average mean defect, 4.5 dB) and 54 eyes of age-matched normal control subjects. The information used included automated visual field indices (mean defect, corrected loss variance, and short-term fluctuation) and structural data (cup/disk ratio, rim area, cup volume, and nerve fiber layer height) from computerized image analysis. A back propagation network with two intermediate layers assigned an estimated probability of being glaucomatous to each eye and correctly identified 88% of all eyes with 90% sensitivity and 84% specificity. The same neural network trained with only structural data correctly identified 80% of the eyes with 87% sensitivity and 56% specificity, and when trained with functional data only, it correctly identified 84% of the eyes with 84% sensitivity and 86% specificity. Analysis of several optic nerve and visual field variables by neural networks can help identify earl...Continue Reading

References

Aug 1, 1979·Archives of Ophthalmology·W M HartB Becker
Apr 1, 1993·Artificial Intelligence in Medicine·J A Reggia

❮ Previous
Next ❯

Citations

Dec 31, 2002·American Journal of Ophthalmology·Amy LinJoseph Caprioli
Jul 7, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Dariusz WroblewskiR Kemp Massengill
Sep 25, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael H GoldbaumWilliam R Freeman
Jun 26, 2007·Seminars in Ophthalmology·C A JohnsonR N Weinreb
Nov 23, 2006·BMC Ophthalmology·Steven E FeldonUNKNOWN Ischemic Optic Neuropathy Decompression Trial Research Group
Feb 15, 2011·BMC Ophthalmology·Michael V Boland, Harry A Quigley
Jul 6, 2004·American Journal of Ophthalmology·Simon K LawJoseph Caprioli
Jun 4, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Christopher Bowd, Michael H Goldbaum
Dec 19, 2018·Current Opinion in Ophthalmology·Chengjie ZhengMichael V Boland
Nov 1, 1996·The British Journal of Ophthalmology·P Undrill
Nov 10, 2004·Eye·C F Burgoyne
Oct 24, 2019·The British Journal of Ophthalmology·Sripad Krishna DevallaMichael J A Girard
Nov 7, 2008·European Journal of Ophthalmology·D S GrewalV Rihani
Aug 29, 2020·Translational Vision Science & Technology·Atalie C ThompsonFelipe A Medeiros
Oct 30, 2020·Translational Vision Science & Technology·Anna S Mursch-EdlmayrHari Jayaram
Sep 9, 2020·Progress in Retinal and Eye Research·Ji-Peng Olivia LiDaniel S W Ting
Jun 23, 2021·Translational Vision Science & Technology·Osamah SaeediTobias Elze

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.